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Clinical and Translational Oncology
Published in: Clinical and Translational Oncology 11/2018

01-11-2018 | Research Article

Radiotherapy volume delineation using 18F-FDG-PET/CT modifies gross node volume in patients with oesophageal cancer

Authors: E. Jimenez-Jimenez, P. Mateos, N. Aymar, R. Roncero, I. Ortiz, M. Gimenez, J. Pardo, J. Salinas, S. Sabater

Published in: Clinical and Translational Oncology | Issue 11/2018

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Abstract

Purpose

Evidence supporting the use of 18F-FDG-PET/CT in the segmentation process of oesophageal cancer for radiotherapy planning is limited. Our aim was to compare the volumes and tumour lengths defined by fused PET/CT vs. CT simulation.

Materials and methods

Twenty-nine patients were analyzed. All patients underwent a single PET/CT simulation scan. Two separate GTVs were defined: one based on CT data alone and another based on fused PET/CT data. Volume sizes for both data sets were compared and the spatial overlap was assessed by the Dice similarity coefficient (DSC).

Results

The gross tumour volume (GTVtumour) and maximum tumour diameter were greater by PET/CT, and length of primary tumour was greater by CT, but differences were not statistically significant. However, the gross node volume (GTVnode) was significantly greater by PET/CT. The DSC analysis showed excellent agreement for GTVtumour, 0.72, but was very low for GTVnode, 0.25.

Conclusions

Our study shows that the volume definition by PET/CT and CT data differs. CT simulation, without taking into account PET/CT information, might leave cancer-involved nodes out of the radiotherapy-delineated volumes.
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Metadata
Title
Radiotherapy volume delineation using 18F-FDG-PET/CT modifies gross node volume in patients with oesophageal cancer
Authors
E. Jimenez-Jimenez
P. Mateos
N. Aymar
R. Roncero
I. Ortiz
M. Gimenez
J. Pardo
J. Salinas
S. Sabater
Publication date
01-11-2018
Publisher
Springer International Publishing
Published in
Clinical and Translational Oncology / Issue 11/2018
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-018-1879-3

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