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01-08-2019 | Lung Cancer | Review Article

The role of immunotherapy in small cell lung cancer

Authors: A. Calles, G. Aguado, C. Sandoval, R. Álvarez

Published in: Clinical and Translational Oncology | Issue 8/2019

Abstract

Despite decades of research, prognosis for SCLC patients remains poor, and treatment options limited. SCLC is an immunogenic tumor with high somatic mutation rates due to tobacco exposure resulting in potential neo-antigens, the presence of suppressed immune responses, and occurrence of paraneoplastic disorders. The use of T cell immune-checkpoint inhibitors (anti-PD1: nivolumab, pembrolizumab; anti-PD-L1: atezolizumab, durvalumab; anti-CTLA-4: ipilimumab, tremelimumab) have shown promising antitumor activity with the potential to prolong survival in SCLC patients. In fact, atezolizumab when combined with chemotherapy has achieved the milestone of being the first drug to improve survival in patients with newly diagnosed extensive-stage SCLC. Other immunotherapeutic approaches evaluated in clinical trials for SCLC include the use of cytokines, cancer vaccines, antiganglioside therapies, TLR9 inhibition, anti-Notch signaling, and anti-CD47. This review discusses the rationale and clinical evidence of immunotherapy in SCLC, the conflictive clinical results of novel immunotherapeutic agents and combinatorial therapies under evaluation in SCLC patients.

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Title: The role of immunotherapy in small cell lung cancer
Authors: A. Calles
G. Aguado
C. Sandoval
R. Álvarez
Publication date: 01-08-2019
Publisher: Springer International Publishing
Keywords: Lung Cancer
Lung Cancer
SCLC
Lung Cancer
SCLC
Checkpoint Inhibitors
Cytostatic Therapy
Published in: Clinical and Translational Oncology / Issue 8/2019
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI: https://doi.org/10.1007/s12094-018-02011-9

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