Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Clinical and Translational Oncology
Published in: Clinical and Translational Oncology 2/2018

01-02-2018 | Research Article

Cancer survival in adult patients in Spain. Results from nine population-based cancer registries

Authors: M. D. Chirlaque, D. Salmerón, J. Galceran, A. Ameijide, A. Mateos, A. Torrella, R. Jiménez, N. Larrañaga, R. Marcos-Gragera, E. Ardanaz, M. Sant, P. Minicozzi, C. Navarro, M. J. Sánchez, the REDECAN Working Group

Published in: Clinical and Translational Oncology | Issue 2/2018

Login to get access

Abstract

Introduction

With the aim of providing cancer control indicators, this work presents cancer survival in adult (≥15 years) patients in Spain diagnosed during the period 2000–2007 from Spanish cancer registries participating in the EUROCARE project.

Methods

Cancer cases from nine Spanish population-based cancer registries were included and analysed as a whole. All primary malignant neoplasms diagnosed in adult patients were eligible for the analysis. Cancer patients were followed until 31 December 2008. For each type of cancer, 1-, 3- and 5-year observed and relative survival were estimated by sex, age and years from diagnosis. Furthermore, age-standardized 5-year relative survival for the period 2000–2007 has been compared with that of the period 1995–1999.

Results

Skin melanoma (84.6 95% CI 83.0–86.2), prostate (84.6% 95% CI 83.6–85.6) and thyroid (84.2% CI 95% 82.0–86.6) cancers showed the highest 5-year relative survival, whereas the worst prognosis was observed in pancreatic (6% 95% CI 5.1–7.0) and oesophageal (9.4% 95% CI 7.9–11.1) cancers. Overall, survival is higher in women (58.0%) than in men (48.9%). The absolute difference in relative survival between 2000–2007 and 1995–1999 was positive for all cancers as a whole (+4.8% in men, +1.6% in women) and for most types of tumours. Survival increased significantly for chronic myeloid leukaemia, non-Hodgkin’s lymphoma and rectum cancer in both sexes, and for acute lymphoid leukaemia, prostate, liver and colon cancers in men and Hodgkin’s lymphoma and breast cancer in women. Survival patterns by age were similar in Europe and Spain. A decline in survival by age was observed in all tumours, being more pronounced for ovarian, corpus uteri, prostate and urinary bladder and less for head and neck and rectum cancers.

Conclusion

High variability and differences have been observed in survival among adults in Spain according to the type of cancer diagnosed, from above 84% to below 10%, reflecting high heterogeneity. The differences in prognosis by age, sex and period of diagnosis reveal opportunities for improving cancer care in Spain.
Appendix
Available only for authorised users
Literature
1.
Navarro C, Martos C, Ardanaz E, Galceran J, Izarzugaza I, Peris-Bonet R, Spanish Cancer Registries Working Group, et al. Population-based cancer registries in Spain and their role in cancer control. Ann Oncol. 2010;21(Suppl 3):iii3–13.PubMed
2.
De Angelis R, Sant M, Coleman MP, Francisci S, Baili P, Pierannunzio D, et al. Cancer survival in Europe 1999–2007 by country and age: results of EUROCARE–5-a population-based study. Lancet Oncol. 2014;15(1):23–34.CrossRefPubMed
3.
Francisci S, Minicozzi P, Pierannunzio D, Ardanaz E, Eberle A, Grimsrud TK, et al. Survival patterns in lung and pleural cancer in Europe 1999–2007: results from the EUROCARE-5 study. Eur J Cancer. 2015;51:2242–53.CrossRefPubMed
4.
Sant M, Chirlaque Lopez MD, Agresti R, Sánchez Pérez MJ, Holleczek B, Bielska-Lasota M, et al. Survival of women with cancers of breast and genital organs in Europe 1999–2007: results of the EUROCARE-5 study. Eur J Cancer. 2015;51:2191–205.CrossRefPubMed
5.
Lepage C, Capocaccia R, Hackl M, Lemmens V, Molina E, Pierannunzio D, et al. Survival in patients with primary liver cancer, gallbladder and extrahepatic biliary tract cancer and pancreatic cancer in Europe 1999–2007: results of EUROCARE-5. Eur J Cancer. 2015;51:2169–78.CrossRefPubMed
6.
Allemani C, Weir HK, Carreira H, Harewood R, Spika D, Wang XS, et al. Global surveillance of cancer survival 1995–2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2). Lancet. 2015;385(9972):977–1010.CrossRefPubMed
7.
Marcos-Gragera R, Salmerón D, Izarzugaza I, Ardanaz E, Serdà BC, Larrañaga N, et al. Trends in prostate cancer survival in Spain: results from population-based cancer registries. Clin Transl Oncol. 2012;14(6):458–64.CrossRefPubMed
8.
Salmerón D, Chirlaque MD, Isabel Izarzugaza M, Sánchez MJ, Marcos-Gragera R, Ardanaz E, et al. Lung cancer prognosis in Spain: the role of histology, age and sex. Respir Med. 2012;106(9):1301–8.CrossRefPubMed
9.
Chirlaque MD, Salmerón D, Ardanaz E, Galceran J, Martínez R, Marcos-Gragera R, et al. Cancer survival in Spain: estimate for nine major cancers. Ann Oncol. 2010;21(Suppl 3):iii21–9.PubMed
10.
11.
12.
Sant M, Allemani C, Santaquilani M, Knijn A, Marchesi F, Capocaccia R, EUROCARE Working Group. EUROCARE-4. Survival of cancer patients diagnosed in 1995–1999. Results and commentary. Eur J Cancer. 2009;45(6):931–91.CrossRefPubMed
13.
Forman D, Bray F, Brewster DH, Gombe Mbalawa C, Kohler B, Piñeros M, et al. editors. Cancer incidence in five continents, vol. X. IARC scientific publication no. 164. Lyon: International Agency for Research on Cancer; 2014.
14.
Rossi S, Baili P, Capocaccia R, Caldora M, Carrani E, Minicozzi P, EUROCARE-5 Working Group, et al. The EUROCARE-5 study on cancer survival in Europe 1999–2007: database, quality checks and statistical analysis methods. Eur J Cancer. 2015;51:2104–19.CrossRefPubMed
15.
Fritz A, Percy C, Jack A, Shanmugaratnam K, Sobin L, Parkin M, et al. International classification of diseases for oncology. 3rd ed. Geneva: World Health Organization. 2000.
16.
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC; 2008.
17.
18.
19.
European Network of Cancer Registries. Guidelines on confidentiality in population-based Cancer Registration in the European Union. Lyon: ENCR; 2002.
20.
Ederer F, Heise H. Instructions to IBM 650 programmers in processing survival computations. Methodological note no. 10. End results evaluation section. National Cancer Institute: Bethseda; 1959.
21.
Corazziari I, Quinn M, Capocaccia R. Standard cancer patient population for age standardising survival ratios. Eur J Cancer. 2004;40(15):2307–16.CrossRefPubMed
22.
Hakulinen T. Cancer survival corrected for heterogeneity in patient withdrawal. Biometrics. 1982;38:933–42.CrossRefPubMed
23.
Parkin DM, Hakulinen T. Cancer registration: principles and methods. Analysis of survival. IARC Sci Publ. 1991;95:159–76.
24.
Crocetti E, Mallone S, Robsahm TE, Gavin A, Agius D, Ardanaz E, EUROCARE Working Group, et al. Survival of patients with skin melanoma in Europe increases further: results of the EUROCARE-5 study. Eur J Cancer. 2015;51:2179–90.CrossRefPubMed
25.
Lyth J, Mikiver R, Nielsen K, Isaksson K, Ingcar C. Prognostic instrument for survival outcome in melanoma patients: base on data from the population-based Swedish Melanoma Register. Eur J Cancer. 2016;59:171–8.CrossRefPubMed
26.
Crocetti E, Fancelli L, Manneschi G, Caldarella A, Pimpinelli N, Chiarugi A, et al. Melanoma survival: sex does matter, but we do not known how. Eur J cáncer Prev. 2016;25(5):404–9.CrossRefPubMed
27.
Avilés-Izquierdo JA, Molina-López I, Rodríguez-Lomba E, Marquez-Rodas I, Suarez-Fernandez R, Lazaro-Ochaita P. Who detects melanoma? Impact of detection patterns on characteristics and prognosis of patients with melanoma. J Am Acad Dermatol. 2016;75(5):967–74.CrossRefPubMed
28.
Nosrati A, Wei ML. Sex disparities in melanoma outcomes: the role of biology. Arch Biochem Biophys. 2014;563:42–50.CrossRefPubMed
29.
Chirlaque MD, Moldenhauer F, Salmerón D, Navarro C. Trends pattern of the incidence of thyroid cancer in Murcia Region (Spain) from 1984 to 2008. Gac Sanit. 2014;28(5):397–400.CrossRefPubMed
30.
Leboulleux S, Tuttle RM, Pacini F, Schlumberger M. Papillary thyroid microcarcinoma: time to shift from surgery to active surveillance? Lancet Diabetes Endocrinol. 2016;4:933–42.CrossRefPubMed
31.
Akhtar-Danesh GG, Finley C, Akhtar-Danesh N. Long-term trends in the incidence and relative survival of pancreatic cancer in Canada: a population-based study. Pancreatology. 2016;16(2):259–65.CrossRefPubMed
32.
Romiti A, Falcone R, Roberto M, Marchetti P. Tackling pancreatic cancer with metronomic chemotherapy. Cancer Lett. 2017;394:88–95.
33.
Zhou B, Xu JW, Cheng YG, Gao JY, Hu SY, Wang L, et al. Early detection of pancreatic cancer: where are we now and where are we going? Int J Cancer. 2017;141:231–41.CrossRefPubMed
34.
Gatta G, Botta L, Sánchez MJ, Anderson LA, Pierannunzio D, Licitra L, the EUROCARE Working Group. Prognoses and improvement for head and neck cancers diagnosed in Europe in early: the EUROCARE-5 population-based study. Eur J Cancer. 2015;51:2130–43.
35.
Guizard AV, Uhry Z, de Raucourt D, Mazzoleni G, Sánchez MJ, Ligier K, GRELL EUROCARE-5 Working Group. Trends in net survival from head and neck cancer in six European Latin countries: results from the SUDCAN population-based study. Eur J Cancer Prev. 2017;26:S16–23.CrossRefPubMed
36.
Anderson LA, Tavilla A, Brenner H, Luttmann S, Navarro C, Gavin AT, EUROCARE-5 Working Group, et al. Survival for oesophageal, stomach and small intestine cancers in Europe 1999–2007: results from EUROCARE-5. Eur J Cancer. 2015;51:2144–57.CrossRefPubMedPubMedCentral
37.
Holleczek B, Rossi S, Domenic A, Innos K, Minicozzi P, Francisci S, EUROCARE-5 Working Group, et al. On-going improvement and persistent differences in the survival for patients with colon and rectum cancer across Europe 1999–2007—results from the EUROCARE-5 study. Eur J Cancer. 2015;51:2158–68.CrossRefPubMed
38.
Antoni S, Ferlay J, Soerjomataram I, Znaor A, Jemal A, Bray F. Bladder cancer incidence and mortality: a global overview and recent trends. Eur Urol. 2017;71(1):96–108.CrossRefPubMed
39.
Marcos-Gragera R, Mallone S, Kiemeney LA, Vilardell L, Malats N, Allory Y, EUROCARE-5 Working Group, et al. Urinary tract cancer survival in Europe 1999–2007: results of the population-based study EUROCARE-5. Eur J Cancer. 2015;51:2217–30.CrossRefPubMed
40.
Visser O, Ardanaz E, Botta L, Sant M, Tavilla A, Minicozzi P, EUROCARE-5 Working Group. Survival of adults with primary malignant brain tumours in Europe; results of the EUROCARE-5 study. Eur J Cancer. 2015;51:2231–41.CrossRefPubMed
41.
Trama A, Foschi R, Larrañaga N, Sant M, Fuentes-Raspall R, Serraino D, EUROCARE-5 Working Group, et al. Survival of male genital cancers (prostate, testis and penis) in Europe 1999–2007: results from the EUROCARE-5 study. Eur J Cancer. 2015;51:2206–16.CrossRefPubMed
42.
Campá J, Mar-Barrutia G, Extramiana J, Arróspide A, Mar J. Advanced prostate cancer survival in Spain according to the Gleason score, age and stage. Actas Urol Esp. 2016;40(8):499–506.CrossRefPubMed
43.
De Angelis R, Francisci S, Baili P, Marchesi F, Roazzi P, Belot A, et al. The EUROCARE-4 database on cancer survival in Europe: data standardisation, quality control and methods of statistical analysis. Eur J Cancer. 2009;45(6):909–30.CrossRefPubMed
44.
De Angelis R, Minicozzi P, Sant M, Dal Maso L, Brewster DH, Osca-Gelis G, EUROCARE-5 Working Group, et al. Survival variations by country and age for lymphoid and myeloid malignancies in Europe 2000–2007: results of EUROCARE-5 population-based study. Eur J Cancer. 2015;51:2254–68.CrossRefPubMed
45.
Osca-Gelis G, Puig-Vives M, Saez M, Gallardo D, Lloveras N, Guàrdia R, et al. Is survival in myeloid malignancies really improving? A retrospective 15-year population-based study. Leuk Lymphoma. 2015;56(4):896–902.CrossRefPubMed
46.
Ellison LF. Differences in cancer survival in Canada by sex. Health Rep. 2016;27(4):19–27.
47.
Oberaigner W, Siebert U. Do women with cancer have better survival as compared to men after adjusting for staging distribution? Eur J Public Health. 2011;21(3):387–91.CrossRefPubMed
48.
Baili P, Di Salvo F, Marcos-Gragera R, Siesling S, Mallone S, Santaquilani M, et al. Age and case mix-standardised survival for all cancer patients in Europe 1999–2007: results of EUROCARE-5, a population-based study. Eur J Cancer. 2015;51:2120–9.CrossRefPubMed
49.
Micheli A, Ciampichini R, Oberaigner W, Ciccolallo L, de Vries E, Izarzugaza I, et al. The advantage of women in cancer survival: an analysis of EUROCARE-4 data. Eur J Cancer. 2009;45(6):1017–27.CrossRefPubMed
50.
Rosso S, De Angelis R, Ciccolallo L, Carrani E, Soerjomataram I, Grande E, EUROCARE Working Group, et al. Multiple tumours in survival estimates. Eur J Cancer. 2009;45(6):1080–94.CrossRefPubMed
51.
Rutherford MJ, Dickman PW, Lambert PC. Comparison of methods for calculating relative survival in population-based studies. Cancer Epidemiol. 2012;36(1):16–21.CrossRefPubMed
Metadata
Title
Cancer survival in adult patients in Spain. Results from nine population-based cancer registries
Authors
M. D. Chirlaque
D. Salmerón
J. Galceran
A. Ameijide
A. Mateos
A. Torrella
R. Jiménez
N. Larrañaga
R. Marcos-Gragera
E. Ardanaz
M. Sant
P. Minicozzi
C. Navarro
M. J. Sánchez
the REDECAN Working Group
Publication date
01-02-2018
Publisher
Springer International Publishing
Published in
Clinical and Translational Oncology / Issue 2/2018
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-017-1710-6

Other articles of this Issue 2/2018

Clinical and Translational Oncology 2/2018 Go to the issue

Research Article

An independent survival prognostic role for human epidermal growth factor receptor 2 in gastric cancer: evidence from a meta-analysis

Research Article

Bevacizumab plus chemotherapy for patients with advanced pulmonary adenocarcinoma harboring EGFR mutations

Brief Research Article

Histopathological factors predicting response to neoadjuvant therapy in gastric carcinoma

Research Article

Long-term clinical benefit from salvage EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer patients with EGFR wild-type tumors

Research Article

The prognostic impact of additional intrathoracic findings in patients with cancer-related pulmonary embolism

Research Article

Treatment strategies for rectal cancer with synchronous liver metastases: surgical and oncological outcomes with propensity-score analysis
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits