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Clinical and Translational Oncology
Published in: Clinical and Translational Oncology 11/2015

01-11-2015 | Review Article

Salivary gland myoepithelial carcinoma

Authors: S. Vilar-González, K. Bradley, J. Rico-Pérez, P. Vogiatzis, D. Golka, A. Nigam, M. Sivaramalingam, S. Kazmi

Published in: Clinical and Translational Oncology | Issue 11/2015

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Abstract

Salivary gland myoepithelial carcinoma (MC) or malignant myoepithelioma is a rare entity. MC usually presents as a slow-growing painless mass arising in the parotid gland, but may involve other salivary glands. This tumour may be particularly locally aggressive, but its clinical and biological features are not yet fully understood. MC may arise from pre-existing benign lesions, such as pleomorphic adenomas or benign myoepitheliomas, or may arise de novo. It usually affects patients over 50 years old, with no gender preference. Because it is often asymptomatic, the presentation and diagnosis can be delayed by months, even years. The current WHO classification considers MC to be an intermediate- to high-grade malignancy. Other published data suggest it is likely to be a high-grade neoplasm, consistent with its aggressive behaviour. Its epidemiology, histopathological features, immunohistochemical profile, clinical behaviour and optimal management are not well understood. Following review of the current literature we aim to address these.
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Metadata
Title
Salivary gland myoepithelial carcinoma
Authors
S. Vilar-González
K. Bradley
J. Rico-Pérez
P. Vogiatzis
D. Golka
A. Nigam
M. Sivaramalingam
S. Kazmi
Publication date
01-11-2015
Publisher
Springer Milan
Published in
Clinical and Translational Oncology / Issue 11/2015
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-015-1329-4

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