Skip to main content
Top
Published in: Clinical and Translational Oncology 4/2015

Open Access 01-04-2015 | Educational Series – Red Series

Preventive treatments for breast cancer: recent developments

Authors: J. E. Alés-Martínez, A. Ruiz, J. I. Chacón, A. Lluch Hernández, M. Ramos, O. Córdoba, E. Aguirre, A. Barnadas, C. Jara, S. González, A. Plazaola, J. Florián, R. Andrés, P. Sánchez Rovira, A. Frau

Published in: Clinical and Translational Oncology | Issue 4/2015

Login to get access

Abstract

Breast cancer is a burden for western societies, and an increasing one in emerging economies, because of its high incidence and enormous psychological, social, sanitary and economic costs. However, breast cancer is a preventable disease in a significant proportion. Recent developments in the armamentarium of effective drugs for breast cancer prevention (namely exemestane and anastrozole), the new recommendation from the National Institute for Health and Care Excellence to use preventative drugs in women at high risk as well as updated Guidelines from the US Preventive Services Task Force and the American Society of Clinical Oncology should give renewed momentum to the pharmacological prevention of breast cancer. In this article we review recent major developments in the field and examine their ongoing repercussion for breast cancer prevention. As a practical example, the potential impact of preventive measures in Spain is evaluated and a course of practical actions is delineated.
Literature
1.
go back to reference Cuzick J, DeCensi A, Arun B, Brown PH, Castiglione M, Dunn B, et al. Preventive therapy for breast cancer: a consensus statement. Lancet Oncol. 2011;12(5):496–503.CrossRefPubMed Cuzick J, DeCensi A, Arun B, Brown PH, Castiglione M, Dunn B, et al. Preventive therapy for breast cancer: a consensus statement. Lancet Oncol. 2011;12(5):496–503.CrossRefPubMed
3.
go back to reference Raphael J, Verma S, Hewitt P, Eisen A. The impact of Angelina Jolie’s (AJ) story on genetic referral and testing at an academic cancer centre. J Clin Oncol. 2014;32. (suppl 26; abstr 44). Raphael J, Verma S, Hewitt P, Eisen A. The impact of Angelina Jolie’s (AJ) story on genetic referral and testing at an academic cancer centre. J Clin Oncol. 2014;32. (suppl 26; abstr 44).
4.
go back to reference Metcalfe K, Gershman S, Ghadirian P, Lynch HT, Snyder C, Tung N, et al. Contralateral mastectomy and survival after breast cancer in carriers of BRCA1 and BRCA2 mutations: retrospective analysis. BMJ. 2014;11(348):g226. doi:10.1136/bmj.g226.CrossRef Metcalfe K, Gershman S, Ghadirian P, Lynch HT, Snyder C, Tung N, et al. Contralateral mastectomy and survival after breast cancer in carriers of BRCA1 and BRCA2 mutations: retrospective analysis. BMJ. 2014;11(348):g226. doi:10.​1136/​bmj.​g226.CrossRef
5.
6.
go back to reference Obermair A, Youlden DR, Baade PD, Janda M. The impact of risk-reducing hysterectomy and bilateral salpingo-oophorectomy on survival in patients with a history of breast cancer—a population-based data linkage study. Int J Cancer. 2014;134(9):2211–22. doi: 10.1002/ijc.28537. Epub 2013 Oct 31. Obermair A, Youlden DR, Baade PD, Janda M. The impact of risk-reducing hysterectomy and bilateral salpingo-oophorectomy on survival in patients with a history of breast cancer—a population-based data linkage study. Int J Cancer. 2014;134(9):2211–22. doi: 10.​1002/​ijc.​28537. Epub 2013 Oct 31.
7.
go back to reference Huzarski T, Byrski T, Gronwald J, Górski B, Domagala P, Cybulski C, et al. Ten-year survival in patients with BRCA1-negative and BRCA1-positive breast cancer. J Clin Oncol. 2013;31(26):3191–6. Huzarski T, Byrski T, Gronwald J, Górski B, Domagala P, Cybulski C, et al. Ten-year survival in patients with BRCA1-negative and BRCA1-positive breast cancer. J Clin Oncol. 2013;31(26):3191–6.
9.
go back to reference Fisher B, Costantino JP, Wickerham DL, Cecchini RS, Cronin WM, Robidoux A, et al. Tamoxifen for the prevention of breast cancer: current status of the national surgical adjuvant breast and bowel project P-1 study. J Natl Cancer Inst. 2005;97(22):1652–62.CrossRefPubMed Fisher B, Costantino JP, Wickerham DL, Cecchini RS, Cronin WM, Robidoux A, et al. Tamoxifen for the prevention of breast cancer: current status of the national surgical adjuvant breast and bowel project P-1 study. J Natl Cancer Inst. 2005;97(22):1652–62.CrossRefPubMed
10.
go back to reference Cuzick J, Forbes JF, Sestak I, Cawthorn S, Hamed H, Holli K, et al. International Breast Cancer Intervention Study I Investigators. Long term results of Tamoxifen prophylaxis for breast cancer96 month follow up of the randomized IBIS-I trial. J Natl Cancer Inst. 2007;99(4):272–82.CrossRefPubMed Cuzick J, Forbes JF, Sestak I, Cawthorn S, Hamed H, Holli K, et al. International Breast Cancer Intervention Study I Investigators. Long term results of Tamoxifen prophylaxis for breast cancer96 month follow up of the randomized IBIS-I trial. J Natl Cancer Inst. 2007;99(4):272–82.CrossRefPubMed
11.
go back to reference Vogel VG, Costantino JP, Wickerham DL, Cronin WM, Cecchini RS, Atkins JN, et al. Effects of Tamoxifen versus raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP study of Tamoxifen and raloxifene (STAR) P-2 trial. JAMA. 2006;295(23):2727–41 Epub 2006 Jun 5.CrossRefPubMed Vogel VG, Costantino JP, Wickerham DL, Cronin WM, Cecchini RS, Atkins JN, et al. Effects of Tamoxifen versus raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP study of Tamoxifen and raloxifene (STAR) P-2 trial. JAMA. 2006;295(23):2727–41 Epub 2006 Jun 5.CrossRefPubMed
12.
go back to reference Costantino JP, Gail MH, Pee D, Anderson S, Redmond CK, Benichou J, et al. Validation studies for models projecting the risk of invasive and total breast cancer incidence. J Natl Cancer Inst. 1999;91:1541–8.CrossRefPubMed Costantino JP, Gail MH, Pee D, Anderson S, Redmond CK, Benichou J, et al. Validation studies for models projecting the risk of invasive and total breast cancer incidence. J Natl Cancer Inst. 1999;91:1541–8.CrossRefPubMed
13.
go back to reference Tyrer J, Duffy SW, Cuzick J. A breast cancer prediction model incorporating familial and personal risk factors. Stat Med. 2004;23:1111–30.CrossRefPubMed Tyrer J, Duffy SW, Cuzick J. A breast cancer prediction model incorporating familial and personal risk factors. Stat Med. 2004;23:1111–30.CrossRefPubMed
14.
go back to reference Boughey JC, Hartmann LC, Anderson SS, Degnim AC, Vierkant RA, Reynolds CA, et al. Evaluation of the Tyrer-Cuzick (International Breast Cancer Intervention Study) model for breast cancer risk prediction in women with atypical hyperplasia. J Clin Oncol. 2010;28:3591–6.CrossRefPubMedCentralPubMed Boughey JC, Hartmann LC, Anderson SS, Degnim AC, Vierkant RA, Reynolds CA, et al. Evaluation of the Tyrer-Cuzick (International Breast Cancer Intervention Study) model for breast cancer risk prediction in women with atypical hyperplasia. J Clin Oncol. 2010;28:3591–6.CrossRefPubMedCentralPubMed
15.
go back to reference Kote-Jarai Z, Powles TJ, Mitchell G, Tidy A, Ashley S, Easton D, et al. BRCA1/BRCA2 mutation status and analysis of cancer family history in participants of the Royal Marsden Hospital tamoxifen chemoprevention trial. Cancer Lett. 2007;247(2):259–65.CrossRefPubMed Kote-Jarai Z, Powles TJ, Mitchell G, Tidy A, Ashley S, Easton D, et al. BRCA1/BRCA2 mutation status and analysis of cancer family history in participants of the Royal Marsden Hospital tamoxifen chemoprevention trial. Cancer Lett. 2007;247(2):259–65.CrossRefPubMed
16.
go back to reference Metcalfe K, Lynch HT, Ghadirian P, Tung N, Olivotto I, Warner E, et al. Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers. J Clin Oncol. 2004;22(12):2328–35.CrossRefPubMed Metcalfe K, Lynch HT, Ghadirian P, Tung N, Olivotto I, Warner E, et al. Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers. J Clin Oncol. 2004;22(12):2328–35.CrossRefPubMed
17.
go back to reference Phillips KA, Milne RL, Rookus MA, Daly MB, Antoniou AC, Peock S, et al. Tamoxifen and risk of contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. J Clin Oncol. 2013;31:3091–9.CrossRefPubMedCentralPubMed Phillips KA, Milne RL, Rookus MA, Daly MB, Antoniou AC, Peock S, et al. Tamoxifen and risk of contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. J Clin Oncol. 2013;31:3091–9.CrossRefPubMedCentralPubMed
18.
go back to reference Vicus D, Rosen B, Lubinski J, Domchek S, Kauff ND, Lynch HT, et al. Tamoxifen and the risk of ovarian cancer in BRCA1 mutation carriers Gynaecological. Oncology. 2009;115(1):135–7. Vicus D, Rosen B, Lubinski J, Domchek S, Kauff ND, Lynch HT, et al. Tamoxifen and the risk of ovarian cancer in BRCA1 mutation carriers Gynaecological. Oncology. 2009;115(1):135–7.
19.
go back to reference Nelson HD, Smith ME, Griffin JC, Fu R. Use of medications to reduce risk for primary breast cancer: a systematic review for the US preventive services task force. Ann Intern Med. 2013;158(8):604–14.CrossRefPubMed Nelson HD, Smith ME, Griffin JC, Fu R. Use of medications to reduce risk for primary breast cancer: a systematic review for the US preventive services task force. Ann Intern Med. 2013;158(8):604–14.CrossRefPubMed
20.
go back to reference Vogel VG, Costantino JP, Wickerham DL, Cronin WM, Cecchini RS, Atkins JN, et al. Update of the national surgical adjuvant breast and bowel project study of tamoxifen and raloxifene (STAR) P-2 Trial: preventing breast cancer, Cancer Prev Res (Phila). 2010;3(6):696–706. doi: 10.1158/1940-6207.CAPR-10-0076. Epub 2010 Apr 19. Vogel VG, Costantino JP, Wickerham DL, Cronin WM, Cecchini RS, Atkins JN, et al. Update of the national surgical adjuvant breast and bowel project study of tamoxifen and raloxifene (STAR) P-2 Trial: preventing breast cancer, Cancer Prev Res (Phila). 2010;3(6):696–706. doi: 10.​1158/​1940-6207.​CAPR-10-0076. Epub 2010 Apr 19.
21.
go back to reference Coopey SB, Mazzola E, Buckley JM, Sharko J, Belli AK, Kim EM, et al. The role of chemoprevention in modifying the risk of breast cancer in women with atypical breast lesions. Breast Cancer Res Treat. 2012;136:627–33.CrossRefPubMed Coopey SB, Mazzola E, Buckley JM, Sharko J, Belli AK, Kim EM, et al. The role of chemoprevention in modifying the risk of breast cancer in women with atypical breast lesions. Breast Cancer Res Treat. 2012;136:627–33.CrossRefPubMed
22.
go back to reference Pastor-Barriuso R, Ascunce N, Ederra M, Erdozáin N, Murillo A, Alés-Martínez JE, et al. Recalibration of the Gail model for predicting invasive breast cancer risk in Spanish women: a population-based cohort study. Breast Cancer Res Treat. 2013;138(1):249–59.CrossRefPubMedCentralPubMed Pastor-Barriuso R, Ascunce N, Ederra M, Erdozáin N, Murillo A, Alés-Martínez JE, et al. Recalibration of the Gail model for predicting invasive breast cancer risk in Spanish women: a population-based cohort study. Breast Cancer Res Treat. 2013;138(1):249–59.CrossRefPubMedCentralPubMed
23.
go back to reference Pollán M, Ascunce N, Ederra M, Murillo A, Erdozáin N, Alés-Martínez JE, et al. Mammographic density and risk of breast cancer according to tumor characteristics and mode of detection: a Spanish population-based case-control study. Breast Cancer Res. 2013;15(1):R9.CrossRefPubMedCentralPubMed Pollán M, Ascunce N, Ederra M, Murillo A, Erdozáin N, Alés-Martínez JE, et al. Mammographic density and risk of breast cancer according to tumor characteristics and mode of detection: a Spanish population-based case-control study. Breast Cancer Res. 2013;15(1):R9.CrossRefPubMedCentralPubMed
24.
go back to reference Goss PE, Ingle JN, Alés-Martínez JE, Cheung AM, Chlebowski RT, Wactawski-Wende J, et al. NCIC CTG MAP.3 Study investigators. Exemestane for breast-cancer prevention in postmenopausal women. N Engl J Med. 2011;364:2381–91.CrossRefPubMed Goss PE, Ingle JN, Alés-Martínez JE, Cheung AM, Chlebowski RT, Wactawski-Wende J, et al. NCIC CTG MAP.3 Study investigators. Exemestane for breast-cancer prevention in postmenopausal women. N Engl J Med. 2011;364:2381–91.CrossRefPubMed
25.
go back to reference Visvanathan K, Hurley P, Bantug E, Brown P, Col NF, Cuzick J, et al. Use of pharmacologic interventions for breast cancer risk reduction: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2013;31:2942–62.CrossRefPubMed Visvanathan K, Hurley P, Bantug E, Brown P, Col NF, Cuzick J, et al. Use of pharmacologic interventions for breast cancer risk reduction: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2013;31:2942–62.CrossRefPubMed
26.
go back to reference Freedman AN, Yu B, Gail MH, Costantino JP, Graubard BI, Vogel VG, et al. Benefit/risk assessment for breast cancer chemoprevention with raloxifene or tamoxifen for women age 50 years or older. J Clin Oncol. 2011;29:2327–33.CrossRefPubMedCentralPubMed Freedman AN, Yu B, Gail MH, Costantino JP, Graubard BI, Vogel VG, et al. Benefit/risk assessment for breast cancer chemoprevention with raloxifene or tamoxifen for women age 50 years or older. J Clin Oncol. 2011;29:2327–33.CrossRefPubMedCentralPubMed
27.
go back to reference Waters EA, McNeel TS, Stevens WM, Freedman AN. Use of tamoxifen and raloxifene for breast cancer chemoprevention in 2010. Breast Cancer Res Treat. 2012;134(2):875–80.CrossRefPubMedCentralPubMed Waters EA, McNeel TS, Stevens WM, Freedman AN. Use of tamoxifen and raloxifene for breast cancer chemoprevention in 2010. Breast Cancer Res Treat. 2012;134(2):875–80.CrossRefPubMedCentralPubMed
28.
go back to reference Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. GLOBOCAN 2008, Cancer incidence and mortality worldwide: IARC CancerBase No. 10. Lyon, France: International Agency for Research on Cancer; 2012. http://globocan.iarc.fr. Accessed 13 Oct 2014. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. GLOBOCAN 2008, Cancer incidence and mortality worldwide: IARC CancerBase No. 10. Lyon, France: International Agency for Research on Cancer; 2012. http://​globocan.​iarc.​fr. Accessed 13 Oct 2014.
29.
go back to reference Alés JE, Ruiz A, Richardson H, Chacón JI, Lluch A, Ramos M, et al. Map.3/Excel/GEICAM 2003–08: an international phase III placebo-controlled breast cancer prevention trial of exemestane in postmenopausal women at risk for breast cancer: results of the Spanish cohort. XIII CONGRESO NACIONAL SEOM. Málaga, 19–21 Oct, 2011. Alés JE, Ruiz A, Richardson H, Chacón JI, Lluch A, Ramos M, et al. Map.3/Excel/GEICAM 2003–08: an international phase III placebo-controlled breast cancer prevention trial of exemestane in postmenopausal women at risk for breast cancer: results of the Spanish cohort. XIII CONGRESO NACIONAL SEOM. Málaga, 19–21 Oct, 2011.
30.
go back to reference Cuzick J, Sestak I, Forbes JF, Dowsett M, Knox J, Cawthorn S, et al. Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): an international, double-blind, randomised placebo-controlled trial. Lancet. 2014;383(9922):1041–8. doi: 10.1016/S0140-6736(13)62292-8. Cuzick J, Sestak I, Forbes JF, Dowsett M, Knox J, Cawthorn S, et al. Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): an international, double-blind, randomised placebo-controlled trial. Lancet. 2014;383(9922):1041–8. doi: 10.​1016/​S0140-6736(13)62292-8.
31.
go back to reference Maunsell E, Goss PE, Chlebowski RT, Ingle J N, Alés-Martínez JE, Sarto GE, et al. Quality of Life in MAP.3 (Mammary Prevention 3): A Randomized, Placebo-Controlled Trial Evaluating Exemestane for Prevention of Breast Cancer. J Clin Oncol 2014;32:1427–36. Maunsell E, Goss PE, Chlebowski RT, Ingle J N, Alés-Martínez JE, Sarto GE, et al. Quality of Life in MAP.3 (Mammary Prevention 3): A Randomized, Placebo-Controlled Trial Evaluating Exemestane for Prevention of Breast Cancer. J Clin Oncol 2014;32:1427–36.
Metadata
Title
Preventive treatments for breast cancer: recent developments
Authors
J. E. Alés-Martínez
A. Ruiz
J. I. Chacón
A. Lluch Hernández
M. Ramos
O. Córdoba
E. Aguirre
A. Barnadas
C. Jara
S. González
A. Plazaola
J. Florián
R. Andrés
P. Sánchez Rovira
A. Frau
Publication date
01-04-2015
Publisher
Springer Milan
Published in
Clinical and Translational Oncology / Issue 4/2015
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-014-1250-2

Other articles of this Issue 4/2015

Clinical and Translational Oncology 4/2015 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine