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Published in: Hepatology International 6/2016

01-11-2016 | Review Article

The potential role of liver stem cells in initiation of primary liver cancer

Authors: Xiao-Song Zhi, Jun Xiong, Xiao-Yuan Zi, Yi-Ping Hu

Published in: Hepatology International | Issue 6/2016

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Abstract

Identification of the cellular origin of primary liver cancer remains challenging. Some data point toward liver stem cells (LSCs) or liver progenitor cells (LPCs) not only as propagators of liver regeneration, but also as initiators of liver cancer. LSCs exhibit a long lifespan and strong duplicative potential upon activation and are inclined to accumulate more mutations that can be passed down to the next generations. Recent evidence shows that dysregulation of signaling pathways associated with self-renewal of LSCs can drive their aberrant proliferation and even malignant transformation. If LSCs could be proved to be an initiator of liver carcinogenesis, they would be promising for ultra-early diagnosis and targeting therapy of liver cancer. This review mainly summarizes the potential role of LSCs in the carcinogenesis of primary liver cancer.
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Metadata
Title
The potential role of liver stem cells in initiation of primary liver cancer
Authors
Xiao-Song Zhi
Jun Xiong
Xiao-Yuan Zi
Yi-Ping Hu
Publication date
01-11-2016
Publisher
Springer India
Published in
Hepatology International / Issue 6/2016
Print ISSN: 1936-0533
Electronic ISSN: 1936-0541
DOI
https://doi.org/10.1007/s12072-016-9730-9

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