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Published in:

01-06-2018 | Review Article

Chimeric antigen receptor T cell therapy in pancreatic cancer: from research to practice

Authors: Vishal Jindal, Ena Arora, Muhammad Masab, Sorab Gupta

Published in: Medical Oncology | Issue 6/2018

Abstract

Chimeric antigen receptor (CAR) T cell therapy is genetically engineered tumor antigen-specific anticancer immunotherapy, which after showing great success in hematological malignancies is currently being tried in advanced solid tumors like pancreatic cancer. Immunosuppressive tumor microenvironment and dense fibrous stroma are some of the limitation in the success of this novel therapy. However, genetic modifications and combination therapy is the topic of the research to improve its efficacy. In this article, we summarize the current state of knowledge, limitations, and future prospects for CAR T cell therapy in pancreatic cancer.

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Title: Chimeric antigen receptor T cell therapy in pancreatic cancer: from research to practice
Authors: Vishal Jindal
Ena Arora
Muhammad Masab
Sorab Gupta
Publication date: 01-06-2018
Publisher: Springer US
Published in: Medical Oncology / Issue 6/2018
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-018-1145-0

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