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Published in: Medical Oncology 8/2015

01-08-2015 | Original Paper

PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma

Authors: Yiwei Wang, Hang Wang, Qi Zhao, Yu Xia, Xiaoyi Hu, Jianming Guo

Published in: Medical Oncology | Issue 8/2015

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Abstract

The incidence of kidney cancer has been increasing globally during the past two decades. Renal cell carcinoma (RCC) is the most aggressive subtype of kidney cancer, which usually deteriorates with epithelial–mesenchymal transition (EMT) that facilitates the migration and invasion of cancer cells. Till now, the underlying mechanism remains unclear. In this study, we demonstrated that programmed death ligand 1 (PD-L1/B7-H1/CD274) could induce EMT and enhance RCC cell cancer stemness through up-regulation of SREBP-1c. Furthermore, we found that PD-L1 is up-regulated in human RCC metastases. These results, taken together, provide evidence for a novel mechanism of PD-L1 in RCC progression, suggesting that there is a close relationship between EMT and immune escape signaling pathways in RCC.
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Metadata
Title
PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma
Authors
Yiwei Wang
Hang Wang
Qi Zhao
Yu Xia
Xiaoyi Hu
Jianming Guo
Publication date
01-08-2015
Publisher
Springer US
Published in
Medical Oncology / Issue 8/2015
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-015-0655-2

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