Published in:
01-01-2015 | Letter to the Editor
Occurrence of BCR/ABL fusion gene in a patient with acute promyelocytic leukemia
Authors:
Li-juan Zhang, Yi-min Gan, Liang Yu
Published in:
Medical Oncology
|
Issue 1/2015
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Excerpt
Acute promyelocytic leukemia (APL) is a common malignant hematological tumor characterized by the t(15;17) chromosome translocation, which results in the fusion of the retinoic acid receptor alpha (
RARα) gene on chromosome 17 and the
PML gene on chromosome 15, with the expression of a PML–RARα fusion protein [
1]. The BCR/ABL fusion gene, which is caused by the t(9;22) chromosome translocation, is mainly found in patients with chronic myeloid leukemia (CML). However, it is also the most common cytogenetic abnormality detected in adult acute lymphoblastic leukemia (about 30 %) and is also observed in a few acute myeloid leukemia (AML) patients. However, BCR/ABL is rarely found in APL. Here, we report the occurrence of both PML–RARα and BCR/ABL in a patient with primary APL. …
