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01-01-2015 | Original Paper

MiR-145 acts as a metastasis suppressor by targeting metadherin in lung cancer

Authors: Mingzhi Wang, Jianhua Wang, Jianming Deng, Xuejun Li, Weiguang Long, Yongmei Chang

Published in: Medical Oncology | Issue 1/2015

Abstract

MiR-145 has been reported to be downregulated in multiple tumors. It acts as a tumor suppressor in lung cancer. In this study, we investigated the potential effects of miR-145 on invasion and metastasis and the molecular mechanism in non-small cell lung cancer. MiR-145 was downregulated in the NSCLC specimens and significantly correlated with advanced clinical stage and lymph node metastasis. In addition, AEG-1/MTDH was a direct target of miR-145, and the expression of AEG-1/MTDH was inversely correlated with miR-145 expression in NSCLC tissues. Ectopic expression of miR-145 suppressed cell invasion and metastasis in NSCLC cells. AEG-1/MTDH overexpression partially reversed the suppressive effect of miR-145. These findings provide novel insights with potential therapeutic applications for the treatment of NSCLC.

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Title: MiR-145 acts as a metastasis suppressor by targeting metadherin in lung cancer
Authors: Mingzhi Wang
Jianhua Wang
Jianming Deng
Xuejun Li
Weiguang Long
Yongmei Chang
Publication date: 01-01-2015
Publisher: Springer US
Published in: Medical Oncology / Issue 1/2015
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-014-0344-6

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