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Medical Oncology
Published in: Medical Oncology 11/2014

01-11-2014 | Original Paper

Cisplatin and paclitaxel target significant long noncoding RNAs in laryngeal squamous cell carcinoma

Authors: Hui Chen, Yuan Xin, Liang Zhou, Jia-meng Huang, Lei Tao, Lei Cheng, Jie Tian

Published in: Medical Oncology | Issue 11/2014

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Abstract

The objectives of this study were to identify specific long noncoding RNAs (lncRNAs) in laryngeal squamous cell carcinoma (LSCC) and to clarify the function of cisplatin and paclitaxel on the confirmed laryngeal cancer lncRNAs. Fifty-four pairs of laryngeal tumor and adjacent normal tissue were collected. Candidate lncRNAs were searched in authorized databases. The significant lncRNAs were identified and confirmed through high-output real-time PCR. Chemotherapy assay evaluated the influences of cisplatin and paclitaxel on the significant lncRNAs. Thirty-seven cancer-related candidate lncRNAs were selected. Three up-expressed and two down-expressed significant lncRNAs were identified and confirmed. The expressions of lncRNA CDKN2B-AS1, HOTAIR and MALAT1 were dramatically reduced with the increasing concentration of cisplatin and paclitaxel and also lengthening of the treatment duration. Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs.
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Metadata
Title
Cisplatin and paclitaxel target significant long noncoding RNAs in laryngeal squamous cell carcinoma
Authors
Hui Chen
Yuan Xin
Liang Zhou
Jia-meng Huang
Lei Tao
Lei Cheng
Jie Tian
Publication date
01-11-2014
Publisher
Springer US
Published in
Medical Oncology / Issue 11/2014
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-014-0246-7

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