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01-08-2014 | Original Paper

Protein overexpression of CIRP and TLR4 in oral squamous cell carcinoma: an immunohistochemical and clinical correlation analysis

Authors: Wen Hao Ren, Lin Mei Zhang, Huai Qin Liu, Ling Gao, Cheng Chen, Cui Qiang, Xiao Long Wang, Chang Yang Liu, Shao Ming Li, Chen Huang, Hong Qi, Ke Qian Zhi

Published in: Medical Oncology | Issue 8/2014

Abstract

Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy. Here, we evaluated the expression of cold-inducible RNA-binding protein (CIRP) and toll-like receptors 4 (TLR4) in OSCC tissues with immunohistochemistry. Using biostatistical methods designed to assess the impact of the expression of CIRP and TLR4 on the prognosis of patients with OSCC and relate that expression to the clinicopathological characteristics of these patients. For the first time, we demonstrated that the expression of CIRP and TLR4 was increased in OSCC and that high levels of CIRP or TLR4 expression were associated with a short survival rate. In addition, we were surprised to find that the levels of expression of CIRP and TLR4 were very similar. The goal of this study was to evaluate whether these two genes may provide clues as to the regulatory mechanisms of OSCC, serve as prognostic markers and establish a new direction for further studies of these biological mechanisms.

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Title: Protein overexpression of CIRP and TLR4 in oral squamous cell carcinoma: an immunohistochemical and clinical correlation analysis
Authors: Wen Hao Ren
Lin Mei Zhang
Huai Qin Liu
Ling Gao
Cheng Chen
Cui Qiang
Xiao Long Wang
Chang Yang Liu
Shao Ming Li
Chen Huang
Hong Qi
Ke Qian Zhi
Publication date: 01-08-2014
Publisher: Springer US
Published in: Medical Oncology / Issue 8/2014
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-014-0120-7

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