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Medical Oncology
Published in: Medical Oncology 8/2014

01-08-2014 | Review Article

Ubiquitination involved enzymes and cancer

Authors: Mei-juan Zhou, Fang-zhi Chen, Han-chun Chen

Published in: Medical Oncology | Issue 8/2014

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Abstract

Ubiquitination is a post-translational modification process that regulates multiple cell functions. It also plays important roles in the development of cancer. Mechanistically, ubiquitination is a complex process that is comprised of a series of events involving ubiquitin-activating enzymes, ubiquitin-conjugating enzymes and ubiquitin ligases. In general, covalent attachment of ubiquitin to the target proteins marks them for degradation. Dysregulation of the ubiquitination process may cause carcinogenesis. In this review, we summarize recent developments in understanding the relationship between ubiquitination enzymes and carcinogenesis.
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Metadata
Title
Ubiquitination involved enzymes and cancer
Authors
Mei-juan Zhou
Fang-zhi Chen
Han-chun Chen
Publication date
01-08-2014
Publisher
Springer US
Published in
Medical Oncology / Issue 8/2014
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-014-0093-6

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