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01-12-2013 | Short Communication

p53 immunohistochemical expression and patient prognosis in esophageal squamous cell carcinoma

Authors: Asuka Murata, Yoshifumi Baba, Masayuki Watanabe, Hironobu Shigaki, Keisuke Miyake, Ryuichi Karashima, Yu Imamura, Satoshi Ida, Takatsugu Ishimoto, Shiro Iwagami, Yasuo Sakamoto, Yuji Miyamoto, Naoya Yoshida, Hideo Baba

Published in: Medical Oncology | Issue 4/2013

Abstract

It is generally accepted that overexpression of p53 protein is associated with poor prognosis in gastric, lung, and other types of cancer. However, the prognostic significance of p53 aberrations in esophageal cancer remains unclear. This is the largest study (n = 266) examining clinical and prognostic features of p53 immunohistochemical expression in esophageal squamous cell carcinoma. In 139 (52 %) esophageal tumors, nuclear immunoreactivity for p53 protein was detected. p53 aberrant expression was not associated with sex, age, preoperative treatment, TNM stage, or histological grade. Furthermore, p53 expression did not correlate with disease-free survival (P = 0.73) or overall survival (P = 0.62). In addition, no significant modification effect by any of the covariates in the survival analysis was observed (all P > 0.15). In conclusion, our large-scale study demonstrates that p53 expression has no impact on the prognosis of esophageal squamous cell carcinoma.

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Title: p53 immunohistochemical expression and patient prognosis in esophageal squamous cell carcinoma
Authors: Asuka Murata
Yoshifumi Baba
Masayuki Watanabe
Hironobu Shigaki
Keisuke Miyake
Ryuichi Karashima
Yu Imamura
Satoshi Ida
Takatsugu Ishimoto
Shiro Iwagami
Yasuo Sakamoto
Yuji Miyamoto
Naoya Yoshida
Hideo Baba
Publication date: 01-12-2013
Publisher: Springer US
Published in: Medical Oncology / Issue 4/2013
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-013-0728-z

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