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Published in:

01-09-2013 | Original Paper

Association analysis between MDR1 genetic variant and breast cancer risk factors in Chinese Han population

Authors: Yi Hu, Jingliang Wang, Haitao Tao, Huan Wang, Xin Zhang, Yao Cheng, Ruixin Li

Published in: Medical Oncology | Issue 3/2013

Abstract

The multidrug resistance 1 gene (MDR1) is an important candidate gene for influencing breast cancer susceptibility. This study aimed to evaluate the association between MDR1 genetic variants and breast cancer susceptibility. A total of 340 breast cancer patients and 348 cancer-free controls were enrolled in this study. The patients’ general characteristics and related risk factors of breast cancer were collected by questionnaires. The c.4125A>C genetic variant was genotyped through created restriction site polymerase chain reaction method. Our data suggest that there are no significant differences in the allelic and genotypic frequencies between breast cancer patients and cancer-free controls. Moreover, the distribution of breast cancer patients’ risk factors is not different among AA, AC, and CC genotypes. These preliminary results suggest that the c.4125A>C genetic variant is not significantly associated with breast cancer susceptibility.

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Title: Association analysis between MDR1 genetic variant and breast cancer risk factors in Chinese Han population
Authors: Yi Hu
Jingliang Wang
Haitao Tao
Huan Wang
Xin Zhang
Yao Cheng
Ruixin Li
Publication date: 01-09-2013
Publisher: Springer US
Published in: Medical Oncology / Issue 3/2013
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-013-0683-8

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