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Published in: Medical Oncology 1/2013

01-03-2013 | Original Paper

High-level expression of periostin is closely related to metastatic potential and poor prognosis of hepatocellular carcinoma

Authors: Yang Lv, Wei Wang, Wei-Dong Jia, Qi-Kai Sun, Jian-Sheng Li, Jin-Liang Ma, Wen-Bin Liu, Hang-Cheng Zhou, Yong-Sheng Ge, Ji-Hai Yu, Hong-Hai Xia, Ge-Liang Xu

Published in: Medical Oncology | Issue 1/2013

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Abstract

Periostin (PN) is a kind of secreted glycoprotein, which is closely related to the metastatic potential and prognosis of many kinds of tumors in recent studies. However, the expression level of PN in hepatocellular carcinoma (HCC) and its correlation with tumor angiogenesis and prognosis remain unclear. Here Immunohistochemistry assay was used to determine the expression of PN in HCC and corresponding adjacent tissues from 71 patients. VEGF and CD34 were only examined in HCC tissues of patients mentioned above. Immunohistochemically, the expression of PN in HCC was judged to be positive in 73.2 % (52/71) compared with 19.7 % (14/71) in corresponding adjacent tissues, and it was associated with tumor nodules (P = 0.070), microvascular invasion (P = 0.013), Edmondson grade (P = 0.003), tumor capsula (P = 0.038) and TNM stage (P = 0.000); besides, tumors with PN-positive group expressed higher VEGF (82.7 vs. 26.3 %, χ 2 = 20.195, P = 0.000) and had higher MVD (80.5 ± 36.5 vs. 24.0 ± 19.9, t = −6.395, P = 0.000) than those in PN-negative group. Kaplan–Meier method was used for survival analysis, and Cox regression model was performed for multivariate survival analysis. In particular, the expression of PN was found to be an independent factor for predicting overall and disease-free survival of HCC. It is possible that the expression level of PN in HCC is associated with tumor metastatic potential and angiogenesis. Its abnormal expression could be a predictive factor to anticipate HCC patient’s prognosis after surgery.
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Metadata
Title
High-level expression of periostin is closely related to metastatic potential and poor prognosis of hepatocellular carcinoma
Authors
Yang Lv
Wei Wang
Wei-Dong Jia
Qi-Kai Sun
Jian-Sheng Li
Jin-Liang Ma
Wen-Bin Liu
Hang-Cheng Zhou
Yong-Sheng Ge
Ji-Hai Yu
Hong-Hai Xia
Ge-Liang Xu
Publication date
01-03-2013
Publisher
Springer US
Published in
Medical Oncology / Issue 1/2013
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-012-0385-7

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