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Published in: Medical Oncology 1/2011

01-12-2011 | Original Paper

A relationship between ABO blood groups and clinicopathologic characteristics of patients with gastric adenocarcinoma in China

Authors: Miao-Zhen Qiu, Dong-Sheng Zhang, Dan-Yun Ruan, Hui-Yan Luo, Zhi-Qiang Wang, Zhi-Wei Zhou, Feng-Hua Wang, Yu-Hong Li, Rui-Hua Xu

Published in: Medical Oncology | Special Issue 1/2011

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Abstract

Little is known about the relationship between ABO blood groups and the clinicopathologic features in gastric adenocarcinoma patients of China. Whether the distribution of ABO blood groups in patients with gastric adenocarcinoma differs from that with benign diseases is also unknown. A total of 474 gastric adenocarcinoma patients and 404 with benign diseases were enrolled for the study. The relationship between patients’ ABO blood groups and the clinicopathologic features was analyzed. The percentage of blood group AB was more common in men of gastric cancer than in benign diseases. The proportion of angiolymphatic invasion among patients with blood group O was significantly lower than those with other blood groups (P = 0.034). Proportion of tumors associated with estrogen receptor (ER), progestogen receptor (PR) and carcinoembryonic antigen (CEA) expression in blood type A was significantly higher than in other blood types (P = 0.002 for ER expression, 0.009 for PR expression, 0.003 for CEA expression). Proportion of tumors associated with serum CEA and CA19-9 elevation in blood type AB was significantly lower than in other blood types (P < 0.001 for serum CEA elevation, 0.005 for CA19-9 elevation). Though there was no significant difference between ABO blood groups and survival of the patients, patients with blood group B had a trend to show superiority in the survival. The significance of ABO blood group distribution might be associated with biological behavior of gastric adenocarcinoma patients. However, it was found not to be a prognosis factor for patients with gastric adenocarcinoma.
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Metadata
Title
A relationship between ABO blood groups and clinicopathologic characteristics of patients with gastric adenocarcinoma in China
Authors
Miao-Zhen Qiu
Dong-Sheng Zhang
Dan-Yun Ruan
Hui-Yan Luo
Zhi-Qiang Wang
Zhi-Wei Zhou
Feng-Hua Wang
Yu-Hong Li
Rui-Hua Xu
Publication date
01-12-2011
Publisher
Springer US
Published in
Medical Oncology / Issue Special Issue 1/2011
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-010-9735-5

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