Skip to main content
Top
Published in: Medical Oncology 1/2011

01-12-2011 | Original Paper

Central nervous system involvement in Hodgkin’s lymphoma

Authors: L. Galán, A. C. Sánchez, B. Cantos, M. Provencio

Published in: Medical Oncology | Special Issue 1/2011

Login to get access

Abstract

Central nervous system involvement in Hodgkin´s lymphoma is extremely rare. We report three cases who had a relapse from the disease involving CNS. The most frequent causes are skull contiguity, meningeal invasion and via the hematogenous route. It is frequent that the association between Epstein–Barr Virus and Hodgkin´s lymphoma, and a biopsy for confirmation, is always required. Diagnostic imaging tests like CT and MRI are useful. The standard treatment remains holocraneal radiotherapy combined with chemotherapy.
Literature
1.
go back to reference Carbone PP, Kaplan HS, Musshoff K, et al. Report of the Committee on Hodgkin’s disease staging classification. Cancer Res. 1971;31:1860–1.PubMed Carbone PP, Kaplan HS, Musshoff K, et al. Report of the Committee on Hodgkin’s disease staging classification. Cancer Res. 1971;31:1860–1.PubMed
2.
go back to reference Lister TA, Crowther D, Sutcliffe SB, et al. Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin’s disease: Cotswolds meeting. J Clin Oncol. 1989;7:1630–6.PubMed Lister TA, Crowther D, Sutcliffe SB, et al. Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin’s disease: Cotswolds meeting. J Clin Oncol. 1989;7:1630–6.PubMed
3.
go back to reference De Vita VT, Serpick A. Combination chemotherapy in the treatment of advanced Hodgkin’s disease. Proc Amer Ass Cancer Res. 1967;8:13. De Vita VT, Serpick A. Combination chemotherapy in the treatment of advanced Hodgkin’s disease. Proc Amer Ass Cancer Res. 1967;8:13.
4.
go back to reference Bonadonna G, Zucali R, Monfardini S, et al. Combination chemotherapy of Hodgkin’s disease with adriamycin, bleomycin, vinblastine, and imidazole carboxamide versus MOPP. Cancer. 1975;36:252–9.PubMedCrossRef Bonadonna G, Zucali R, Monfardini S, et al. Combination chemotherapy of Hodgkin’s disease with adriamycin, bleomycin, vinblastine, and imidazole carboxamide versus MOPP. Cancer. 1975;36:252–9.PubMedCrossRef
5.
go back to reference Kaplan HS, Rosenberg SA. Extended field radical radiotherapy in advanced Hodgkin’s disease. Cancer Res. 1966;26:1268–76.PubMed Kaplan HS, Rosenberg SA. Extended field radical radiotherapy in advanced Hodgkin’s disease. Cancer Res. 1966;26:1268–76.PubMed
6.
go back to reference Aragón de la Cruz G, Cardenes H, Otero J, et al. Individual risk of abdominal disease in patients with stages I and II supradiaphragmatic Hodgkin’s disease a rule index based on 341 laparotomized patients. Cancer. 1989;63:1799–803.PubMedCrossRef Aragón de la Cruz G, Cardenes H, Otero J, et al. Individual risk of abdominal disease in patients with stages I and II supradiaphragmatic Hodgkin’s disease a rule index based on 341 laparotomized patients. Cancer. 1989;63:1799–803.PubMedCrossRef
7.
go back to reference Johnson MD, Kinney MC, Scheithauer BW, Briley RJ, Hamilton K, Mc Person WF, Barton JH Jr. Primary intracerebral Hodgkin’s disease mimicking meningioma: Case report. Neurosurgery. 2000;47(2):454–6.PubMedCrossRef Johnson MD, Kinney MC, Scheithauer BW, Briley RJ, Hamilton K, Mc Person WF, Barton JH Jr. Primary intracerebral Hodgkin’s disease mimicking meningioma: Case report. Neurosurgery. 2000;47(2):454–6.PubMedCrossRef
8.
go back to reference Cuttner J, Meyer R, Huang YP. Intracerebral involvement in Hodgkin’s disease: A report of 6 cases and review of the literature. Cancer. 1979;43(4):1497–506.PubMedCrossRef Cuttner J, Meyer R, Huang YP. Intracerebral involvement in Hodgkin’s disease: A report of 6 cases and review of the literature. Cancer. 1979;43(4):1497–506.PubMedCrossRef
9.
go back to reference Biagi J, MacKenzie R, Lim MS, Sapp M, Berinstein N. Primary Hodgkin’s disease of the CNS in an immunocompetent patient: A case study review of the literature. Neuro-Oncology. 2000;2(4):239–43.PubMed Biagi J, MacKenzie R, Lim MS, Sapp M, Berinstein N. Primary Hodgkin’s disease of the CNS in an immunocompetent patient: A case study review of the literature. Neuro-Oncology. 2000;2(4):239–43.PubMed
10.
go back to reference Hirmiz K, Foyle A, Wilke D, Burrell S, Brownstone R, Ago C, et al. Intracranial presentation of systemic Hodgkin’s disease. Leukemia, Lymphoma. 2004;45(8):1667–71.CrossRef Hirmiz K, Foyle A, Wilke D, Burrell S, Brownstone R, Ago C, et al. Intracranial presentation of systemic Hodgkin’s disease. Leukemia, Lymphoma. 2004;45(8):1667–71.CrossRef
11.
go back to reference Sapozink MD, Kaplan HS. Intracraneal Hodgkin’s disease: A report of 12 cases and review of the literature. Cancer. 1983;52:1301–7.PubMedCrossRef Sapozink MD, Kaplan HS. Intracraneal Hodgkin’s disease: A report of 12 cases and review of the literature. Cancer. 1983;52:1301–7.PubMedCrossRef
12.
go back to reference Alvarez F, Road JM, Ancines B, Alvarez MP. Intracranial Hodgkin disease. J Neurosurg Sci. 1985;29:273–7.PubMed Alvarez F, Road JM, Ancines B, Alvarez MP. Intracranial Hodgkin disease. J Neurosurg Sci. 1985;29:273–7.PubMed
13.
go back to reference Ogata H, Karikomi M, Araki T, Uchiyama GA. Case of intracranial involvement of Hodgkin disease. Radiat Med. 1993;11:210–3.PubMed Ogata H, Karikomi M, Araki T, Uchiyama GA. Case of intracranial involvement of Hodgkin disease. Radiat Med. 1993;11:210–3.PubMed
14.
go back to reference Klein R, Mullges W, Bendszus M, et al. Primary intracerebral Hodgkin’s disease: Report of a case with Epstein-Barr virus association and review of the literature. Am J Surg Pathol. 1999;23:477–81.PubMedCrossRef Klein R, Mullges W, Bendszus M, et al. Primary intracerebral Hodgkin’s disease: Report of a case with Epstein-Barr virus association and review of the literature. Am J Surg Pathol. 1999;23:477–81.PubMedCrossRef
15.
go back to reference Apollonsky N, Edelman M, Johnson A, et al. Intracerebral presentation of Hodgkin disease mimicking meningioma in a young woman. J Pediatr Hematol Oncol. 2008;30:369–72.PubMedCrossRef Apollonsky N, Edelman M, Johnson A, et al. Intracerebral presentation of Hodgkin disease mimicking meningioma in a young woman. J Pediatr Hematol Oncol. 2008;30:369–72.PubMedCrossRef
16.
go back to reference Pansegrau, et al. Hodgkin’s Lymphoma involving the CNS. J Clin Oncol. 2007;25(11):1437–8.CrossRef Pansegrau, et al. Hodgkin’s Lymphoma involving the CNS. J Clin Oncol. 2007;25(11):1437–8.CrossRef
17.
go back to reference Guermazi A, Brice P, Kerviler E, et al. Extranodal Hodgkin disease: Spectrum of disease. RadioGraphics. 2001;21:161–79.PubMed Guermazi A, Brice P, Kerviler E, et al. Extranodal Hodgkin disease: Spectrum of disease. RadioGraphics. 2001;21:161–79.PubMed
18.
19.
go back to reference Marshall G, Roessmann V, van den Noort S. Invasive Hodgkin’s disease of the brain. Report of 2 new cases and review of the American and European literature with clinical-pathological correlation. Cancer. 1968;2:621–30.CrossRef Marshall G, Roessmann V, van den Noort S. Invasive Hodgkin’s disease of the brain. Report of 2 new cases and review of the American and European literature with clinical-pathological correlation. Cancer. 1968;2:621–30.CrossRef
20.
21.
go back to reference Orlowski EP, Hansen RM, Anderson T, Hanson GA, Kun LE, Pisciotta AV. Hodgkin disease with leptomeningeal involvement, report of a case with long survival. Cancer. 1984;53:1833–5.PubMedCrossRef Orlowski EP, Hansen RM, Anderson T, Hanson GA, Kun LE, Pisciotta AV. Hodgkin disease with leptomeningeal involvement, report of a case with long survival. Cancer. 1984;53:1833–5.PubMedCrossRef
22.
go back to reference Chim CS, Shek TW, Ooi GC, Liang R. Unusual features of Hodgkin disease. Case 2: Meningeal relapse in Hodgkin disease. J Clin Oncol. 2000;18:1153–5.PubMed Chim CS, Shek TW, Ooi GC, Liang R. Unusual features of Hodgkin disease. Case 2: Meningeal relapse in Hodgkin disease. J Clin Oncol. 2000;18:1153–5.PubMed
23.
go back to reference Vera R, Enriquez R, Papc R. Hodgkin’s disease, intracraneal involvement. Report of a case and review of the literature. Am J Clin Oncol. 1985;8:73–6.PubMedCrossRef Vera R, Enriquez R, Papc R. Hodgkin’s disease, intracraneal involvement. Report of a case and review of the literature. Am J Clin Oncol. 1985;8:73–6.PubMedCrossRef
Metadata
Title
Central nervous system involvement in Hodgkin’s lymphoma
Authors
L. Galán
A. C. Sánchez
B. Cantos
M. Provencio
Publication date
01-12-2011
Publisher
Springer US
Published in
Medical Oncology / Issue Special Issue 1/2011
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-010-9692-z

Other articles of this Special Issue 1/2011

Medical Oncology 1/2011 Go to the issue