Skip to main content
Top
Published in: Medical Oncology 1/2011

01-12-2011 | Original paper

Primary primitive neuroectodermal tumor of the urinary bladder: a case report and literature review

Authors: Yulong Zheng, Fuqing Tan, Lijun Wang, Nong Xu, Haibo Mou

Published in: Medical Oncology | Special Issue 1/2011

Login to get access

Abstract

Primitive neuroectodermal tumor (PNET) arising in the urinary bladder is extremely rare. Here, we report a case of primary PNET of the urinary bladder in an aged Asian man that showed an aggressive clinical course. A 74-year-old man presented with frequency, dysuria, and gross hematuria. Pelvic computed tomography showed a mass in the urinary bladder. Microscopically, the tumor revealed sheets of uniform, small, round, blue cells, and immunohistochemical examination demonstrated primary PNET of the urinary bladder. Palliative chemotherapy was administered. After three courses of chemotherapy, his disease progressed and he died 4 months after diagnosis.
Literature
1.
go back to reference Ellinger J, Bastian PJ, Hauser S, Biermann K, Müller SC. Primitive neuroectodermal tumor: rare, highly aggressive differential diagnosis in urologic malignancies. Urology. 2006;68:257–62.PubMedCrossRef Ellinger J, Bastian PJ, Hauser S, Biermann K, Müller SC. Primitive neuroectodermal tumor: rare, highly aggressive differential diagnosis in urologic malignancies. Urology. 2006;68:257–62.PubMedCrossRef
2.
go back to reference Banerjee SS, Eyden BP, McVey RJ, Bryden AA, Clarke NW. Primary peripheral primitive neuroectodermal tumour of urinary bladder. Histopathology. 1997;30:486–90.PubMedCrossRef Banerjee SS, Eyden BP, McVey RJ, Bryden AA, Clarke NW. Primary peripheral primitive neuroectodermal tumour of urinary bladder. Histopathology. 1997;30:486–90.PubMedCrossRef
3.
go back to reference Gousse AE, Roth DR, Popek EJ, Cooley LD, Horowitz ME. Primary Ewing’s sarcoma of the bladder associated with an elevated antinuclear antibody titer. J Urol. 1997;158:2265–6.PubMedCrossRef Gousse AE, Roth DR, Popek EJ, Cooley LD, Horowitz ME. Primary Ewing’s sarcoma of the bladder associated with an elevated antinuclear antibody titer. J Urol. 1997;158:2265–6.PubMedCrossRef
4.
go back to reference Mentzel T, Flaschka J, Mentzel HJ, Eschholz G, Katenkamp D. Primary primitive neuroectodermal tumor of the urinary bladder. Clinicopathologic case report and differential small cell tumor diagnosis of this site. Pathologe. 1998;19:154–8.PubMedCrossRef Mentzel T, Flaschka J, Mentzel HJ, Eschholz G, Katenkamp D. Primary primitive neuroectodermal tumor of the urinary bladder. Clinicopathologic case report and differential small cell tumor diagnosis of this site. Pathologe. 1998;19:154–8.PubMedCrossRef
5.
go back to reference Desai S. Primary primitive neuroectodermal tumour of the urinary bladder. Histopathology. 1998;32:477–8.PubMedCrossRef Desai S. Primary primitive neuroectodermal tumour of the urinary bladder. Histopathology. 1998;32:477–8.PubMedCrossRef
6.
go back to reference Colecchia M, Dagrada GP, Poliani PL, Pilotti S. Immunophenotypic and genotypic analysis of a case of primary peripheral primitive neuroectodermal tumour (pPNET) of the urinary bladder. Histopathology. 2002;40:108–9.PubMedCrossRef Colecchia M, Dagrada GP, Poliani PL, Pilotti S. Immunophenotypic and genotypic analysis of a case of primary peripheral primitive neuroectodermal tumour (pPNET) of the urinary bladder. Histopathology. 2002;40:108–9.PubMedCrossRef
7.
go back to reference Krüger S, Schmidt H, Kausch I, Böhle A, Holzhausen HJ, Johannisson R, et al. Primitive neuroectodermal tumor (PNET) of the urinary bladder. Pathol Res Pract. 2003;199:751–4.PubMedCrossRef Krüger S, Schmidt H, Kausch I, Böhle A, Holzhausen HJ, Johannisson R, et al. Primitive neuroectodermal tumor (PNET) of the urinary bladder. Pathol Res Pract. 2003;199:751–4.PubMedCrossRef
8.
go back to reference Lopez-Beltran A, Pérez-Seoane C, Montironi R, Hernández-Iglesias T, Mackintosh C, de Alava E. Primary primitive neuroectodermal tumour of the urinary bladder: a clinico-pathological study emphasising immunohistochemical, ultrastructural and molecular analyses. J Clin Pathol. 2006;59:775–8.PubMedCrossRef Lopez-Beltran A, Pérez-Seoane C, Montironi R, Hernández-Iglesias T, Mackintosh C, de Alava E. Primary primitive neuroectodermal tumour of the urinary bladder: a clinico-pathological study emphasising immunohistochemical, ultrastructural and molecular analyses. J Clin Pathol. 2006;59:775–8.PubMedCrossRef
9.
go back to reference Ushigome U, Machinami R, Sorensen PH. Ewing sarcoma/primitive neuroectodermal tumour (PNET). In: Fletcher CDM, Unni KK, Mertens F, editors. Pathology and Genetics of Tumours of Soft Tissue and Bone (World Health Organization Classification of Tumours). Lyon: International Agency for Research on Cancer Press; 2002. p. 298–300. Ushigome U, Machinami R, Sorensen PH. Ewing sarcoma/primitive neuroectodermal tumour (PNET). In: Fletcher CDM, Unni KK, Mertens F, editors. Pathology and Genetics of Tumours of Soft Tissue and Bone (World Health Organization Classification of Tumours). Lyon: International Agency for Research on Cancer Press; 2002. p. 298–300.
10.
go back to reference Grier HE, Link MP, Gebhardt MC, Meyers PA, Rausen AR. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med. 2003;348:694–701PubMedCrossRef Grier HE, Link MP, Gebhardt MC, Meyers PA, Rausen AR. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med. 2003;348:694–701PubMedCrossRef
11.
go back to reference Ludwig JA. Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future. Curr Opin Oncol. 2008;20:412–8.PubMedCrossRef Ludwig JA. Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future. Curr Opin Oncol. 2008;20:412–8.PubMedCrossRef
Metadata
Title
Primary primitive neuroectodermal tumor of the urinary bladder: a case report and literature review
Authors
Yulong Zheng
Fuqing Tan
Lijun Wang
Nong Xu
Haibo Mou
Publication date
01-12-2011
Publisher
Springer US
Published in
Medical Oncology / Issue Special Issue 1/2011
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-010-9680-3

Other articles of this Special Issue 1/2011

Medical Oncology 1/2011 Go to the issue