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Medical Oncology
Published in: Medical Oncology 2/2011

01-06-2011 | Original Paper

Acquired hemophagocytic lymphohistiocytosis associated with multiple myeloma

Authors: Maciej Machaczka, Johan Vaktnäs, Monika Klimkowska, Hareth Nahi, Hans Hägglund

Published in: Medical Oncology | Issue 2/2011

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Abstract

Acquired or secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening hyperinflammation syndrome caused mostly by various infectious agents, autoimmune disorders or malignancy. So far, only anecdotal cases of sHLH associated with multiple myeloma have been published. We provide a review of all these reports and include a previously not published case of myeloma-associated sHLH in a 59-year-old male with complex partial epilepsy. Due to aggressive course of sHLH, increased awareness is indicated in all patients with malignancies which develop unremitting fever, cytopenia and splenomegaly. Early diagnosis and immediate introduction of adequate therapy is crucial for the outcome of HLH.
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Metadata
Title
Acquired hemophagocytic lymphohistiocytosis associated with multiple myeloma
Authors
Maciej Machaczka
Johan Vaktnäs
Monika Klimkowska
Hareth Nahi
Hans Hägglund
Publication date
01-06-2011
Publisher
Springer US
Published in
Medical Oncology / Issue 2/2011
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-010-9484-5

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