Top

Published in:

01-12-2010 | Case Report

Acute renal failure related to oxaliplatin-induced intravascular hemolysis

Authors: Ayhan Ulusakarya, Srimanta Misra, Mazen Haydar, Hélène Habert, Vincent Castagne, Yusuf Gumus, Béatrice Delmas-Marsalet, David Machover

Published in: Medical Oncology | Issue 4/2010

Abstract

Oxaliplatin is an effective chemotherapeutic agent frequently used in the treatment of colorectal carcinoma. Rare cases of renal failure and hemolytic reactions have been reported as separate side effects of oxaliplatin. Here we present a clinical picture of immune-related intravascular hemolysis and acute tubular necrosis in a patient receiving this drug. This case suggests a mechanistic explanation of renal failure in patients treated with oxaliplatin.

Pinotti G, Martinelli B. A case of acute tubular necrosis due to oxaliplatin. Ann Oncol. 2002;13:1951.CrossRefPubMed

Labaye J, Sarret D, Duvic C, Hérody M, Didelot F, Nédélec G, et al. Renal toxicity of oxaliplatin. Nephrol Dial Transplant. 2005;20:1275–6.CrossRefPubMed

Chen VMY, Thrift KM, Morel-Kopp MC, Jackson D, Ward CM, Flower RL. An immediate hemolytic reaction induced by repeated administration of oxaliplatin. Transfusion. 2004;44:838–43.CrossRefPubMed

Cobo F, De Celis G, Pereira A, Latorre X, Pujadas J, Albiol S. Oxaliplatin-induced immune hemolytic anemia: a case report and review of the literature. Anticancer Drugs. 2007;18:973–6.PubMed

Arndt P, Garraty G, Isaak E, Bolger M, Lu Q. Positive direct and indirect antiglobulin tests associated with oxaliplatin can be due to drug antibody and/or drug-induced nonimmunologic protein adsorbtion. Transfusion. 2009;49:711–8.CrossRefPubMed

Title: Acute renal failure related to oxaliplatin-induced intravascular hemolysis
Authors: Ayhan Ulusakarya
Srimanta Misra
Mazen Haydar
Hélène Habert
Vincent Castagne
Yusuf Gumus
Béatrice Delmas-Marsalet
David Machover
Publication date: 01-12-2010
Publisher: Springer US
Published in: Medical Oncology / Issue 4/2010
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-009-9263-3

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Acute renal failure related to oxaliplatin-induced intravascular hemolysis

Abstract

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 4/2010

The effect of peripheral blood values on prognosis of patients with locally advanced gastric cancer before treatment

Neoadjuvant chemotherapy with a combination of docetaxel, cisplatin, fluorouracil, and leucovorin in nonresectable advanced gastric cancer: a short communication

Clinicopathological analysis of primary epithelial appendiceal neoplasms

Increased prostate-specific membrane antigen expression in LNCaP cells following treatment with bispecific antisense oligonucleotides directed against bcl-2 and EGFR

Discovery of a set of biomarkers of human lung adenocarcinoma through cell-map proteomics and bioinformatics

The efficacy of frontline platinum-based combination chemotherapy in advanced adenocarcinoma of the ampulla of Vater

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page