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01-09-2008 | CASE REPORT

Unusual presentation of metastatic hepatocellular carcinoma in the nasal septum: a case report and review of the literature

Authors: Ching-Wei Chang, Tsang-En Wang, Li-Tzong Chen, Wen-Hsiung Chang, Yi-Shing Leu, Yang-Kai Fan, Yu-Jan Chan

Published in: Medical Oncology | Issue 3/2008

Abstract

Hepatocellular carcinoma with sinonasal metastasis is extremely rare. We report a case of a 49-year-old man who had a history of synchronous hepatocellular carcinoma and verrucous carcinoma of tongue. A painless and non-bleeding mass was found in the left nasal septum 16 months after hepatocellular carcinoma was diagnosed. On computed tomography, the mass was enhanced with contrast. It was resected and proved to be metastatic hepatocellular carcinoma. The patient was treated with radiotherapy to the nasal area and then with chemotherapy. He was still alive, 15 months after the appearance of the nasal metastasis.

Katyal S, et al. Extrahepatic metastases of hepatocellular carcinoma. Radiology 2000;216:698–703.PubMed

Shuto T, et al. Treatment of adrenal metastases after hepatic resection of a hepatocellular carcinoma. Dig Surg 2001;18:294–97.PubMedCrossRef

Nakashima T, et al. Pathology of hepatocellular carcinoma in Japan. 232 consecutive cases autopsied in ten years. Cancer 1983;51:863–77.PubMedCrossRef

Lin CD, Cheng KS, Tsai CH, Chen CL, Tsai MH. Metastatic hepatocellular carcinoma in the nasal septum: report of a case. J Formos Med Assoc 2002;101:715–8.PubMed

Huang HH, Chang PH, Fang TJ. Sinonasal metastatic hepatocellular carcinoma. Am J Otolaryngol 2007;28:238–41.PubMedCrossRef

Matsuda H, Tanigaki Y, Yoshida T, Matsuda R, Tsukuda M. A case of metastatic hepatocellular carcinoma in the nasal cavity. Eur Arch Otorhinolaryngol 2006;263:305–7.PubMedCrossRef

Komura T, et al. A case of nasal metastasis of hepatocellular carcinoma that was treated under transcatheter arterial embolization for control nasal bleeding. Nippon Shokakibyo Gakkai Zasshi 2005;102:1055–61.PubMed

Yoo SJ, et al. Extrahepatic metastasis of hepatocellular carcinoma to the nasal cavity manifested as massive epistaxis: a case report. Korean J Hepatol 2004;10:228–32.PubMed

Okada H, et al. Metastatic hepatocellular carcinoma of the maxillary sinus: a rare autopsy case without lung metastasis and a review. Int J Oral Maxillofac Surg 2003;32:97–100.PubMedCrossRef

10.

Kleinjung T, Held P. Metastasis in the frontal skull base from hepatocellular carcinoma. HNO 2001;49:126–9.PubMedCrossRef

11.

Izquierdo J, Armengot M, Cors R, Perez A, Basterra J. Hepatocarcinoma: metastasis to the nose and paranasal sinuses. Otolaryngol Head Neck Surg 2000;122:932–3.PubMedCrossRef

12.

English JC 3rd, Meyer C, Lewey SM, Zinn CJ. Gingival lesions and nasal obstruction in an immunosuppressed patient post-liver transplantation. Cutis 2000;65:107–9.PubMed

13.

Patankar T, Prasad S, Patni S, James P. Hypervascular nasal metastasis from hepatocellular carcinoma. Indian J Gastroenterol 1998;17:111–2.PubMed

14.

Sim RS, Tan HK. A case of metastatic hepatocellular carcinoma of the sphenoid sinus. J Laryngol Otol 1994;108:503–4.PubMedCrossRef

15.

Mochimatsu I, Tsukuda M, Furukawa S, Sawaki S. Tumours metastasizing to the head and neck—a report of seven cases. J Laryngol Otol 1993;107:1171–3.PubMed

16.

Knobber D, Jahnke V. Metastasis to the ENT area. HNO 1991;39:263–5.PubMed

17.

Frigy AF. Metastatic hepatocellular carcinoma of the nasal cavity. Arch Otolaryngol 1984;110:624–7.PubMed

18.

Nahum AM, Bailey BJ. Malignant tumors metastatic to the paranasal sinuses: case report and review of the literature. Laryngoscope 1963;73:942–53.PubMedCrossRef

19.

Bernstein JM, Montgomery WW, Balogh K Jr. Metastatic tumors to the maxilla, nose, and paranasal sinuses. Laryngoscope 1966;76:621–50.PubMedCrossRef

20.

Batsakis JG, Hybels R, Crissman JD, Rice DH. The pathology of head and neck tumors: verrucous carcinoma, Part 15. Head Neck Surg 1982;5:29–38.PubMedCrossRef

21.

Medina JE, Dichtel W, Luna MA. Verrucous–squamous carcinomas of the oral cavity. A clinicopathologic study of 104 cases. Arch Otolaryngol 1984;110:437–40.PubMed

22.

Jones AS, et al. Second primary tumors in patients with head and neck squamous cell carcinoma. Cancer 1995;75:1343–53.PubMedCrossRef

23.

Natsuizaka M, et al. Clinical features of hepatocellular carcinoma with extrahepatic metastases. J Gastroenterol Hepatol 2005;20:1781–7.PubMedCrossRef

24.

Blum HE. Hepatocellular carcinoma: therapy and prevention. World J Gastroenterol 2005;11:7391–400.PubMed

25.

Wang TE, et al. Salvage therapy for hepatocellular carcinoma with thalidomide. World J Gastroenterol 2004;10:649–53.PubMed

26.

Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet 2003;362:1907–17.PubMedCrossRef

27.

Tangkijvanich P, Mahachai V, Suwangool P, Poovorawan Y. Gender difference in clinicopathologic features and survival of patients with hepatocellular carcinoma. World J Gastroenterol 2004;10:1547–50.PubMed

28.

Tarao K, et al. The male preponderance in incidence of hepatocellular carcinoma in cirrhotic patients may depend on the higher DNA synthetic activity of cirrhotic tissue in men. Cancer 1993;72:369–74.PubMedCrossRef

29.

Matsumoto T, Takagi H, Mori M. Androgen dependency of hepatocarcinogenesis in TGFalpha transgenic mice. Liver 2000;20:228–33.PubMedCrossRef

30.

Cong WM, Wu MC, Zhang XH, Chen H, Yuan JY. Primary hepatocellular carcinoma in women of mainland China. A clinicopathologic analysis of 104 patients. Cancer 1993;71:2941–5.PubMedCrossRef

31.

Lai CL, et al. Hepatocellular carcinoma in Chinese males and females. Possible causes for the male predominance. Cancer 1987;60:1107–10.PubMedCrossRef

32.

Yuki K, Hirohashi S, Sakamoto M, Kanai T, Shimosato Y. Growth and spread of hepatocellular carcinoma. A review of 240 consecutive autopsy cases. Cancer 1990;66:2174–9.PubMedCrossRef

33.

Kew MC. Virchow–Troisier’s lymph node in hepatocellular carcinoma. J Clin Gastroenterol 1991;13:217–9.PubMedCrossRef

34.

Ikai I, et al. Report of the 16th follow-up survey of primary liver cancer. Hepatol Res 2005;32:163–72.PubMedCrossRef

35.

Ikai I, et al. Reevaluation of prognostic factors for survival after liver resection in patients with hepatocellular carcinoma in a Japanese nationwide survey. Cancer 2004;101:796–802.PubMedCrossRef

36.

Yoshimura Y, Matsuda S, Naitoh S. Hepatocellular carcinoma metastatic to the mandibular ramus and condyle: report of a case and review of the literature. J Oral Maxillofac Surg 1997;55:297–306.PubMedCrossRef

Title: Unusual presentation of metastatic hepatocellular carcinoma in the nasal septum: a case report and review of the literature
Authors: Ching-Wei Chang
Tsang-En Wang
Li-Tzong Chen
Wen-Hsiung Chang
Yi-Shing Leu
Yang-Kai Fan
Yu-Jan Chan
Publication date: 01-09-2008
Publisher: Humana Press Inc
Published in: Medical Oncology / Issue 3/2008
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-007-9028-9

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