Invasive Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas Causing Duodenal Infiltration and Obstruction: a Case Report

Excerpt

Intraductal papillary mucinous neoplasms (IPMNs) are rare group of pancreatic epithelial neoplasm characterized by mucin production and diffuse or segmental involvement of the main pancreatic duct (MPD) or major side branches. It comprises only 1–2% of all exocrine pancreatic neoplasm and around 20 to 50% of all cystic pancreatic neoplasm [1, 2]. Histologically, IPMNs are composed of mucin-producing columnar cells showing papillary proliferation, cyst formation, and varying degree of cellular atypia. They follow an orderly progression from low grade to moderate dysplasia to high-grade dysplasia, and finally to invasive carcinoma. Hence, these lesions can be identified grossly and radiographically before the development of invasive cancer, providing an opportunity for early interventions, analogous to colonic cancer [2]. …