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Published in: Journal of Gastrointestinal Cancer 1/2019

01-03-2019 | Case Report

Posterior Reversible Encephalopathy Syndrome During Treatment with Aflibercept, 5-Fluorouracil, Leucovorin, and Irinotecan for Metastatic Colorectal Cancer

Authors: Nikolaos Miaris, Joseph Sgouros, Margarita Gerolympou, Basilios Spyropoulos, Dionysios Drakopoulos, Stefania Gkoura, Helen Res, Epaminondas Samantas

Published in: Journal of Gastrointestinal Cancer | Issue 1/2019

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Excerpt

Posterior reversible encephalopathy syndrome (PRES) is an urgent neurologic condition that is associated with white and gray matter vasogenic edema primarily in parietal and occipital lobes [1]. Clinical features usually involve headache, altered mental status, seizures, and visual disturbances [1]. Although PRES is generally a rare reversible condition, it is increasingly reported in the literature, especially in the setting of cancer patients treated with chemotherapy and antiangiogenic drugs targeting the vascular endothelial growth factor (VEGF) pathway. …
Literature
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go back to reference Miaris N, Maltezou M, Papaxoinis G, et al. Posterior reversible encephalopathy syndrome with concurrent nephrotic syndrome in a patient treated with pazopanib for metastatic renal cell carcinoma: case report and review of the literature. Clin Genitourin Cancer. 2017; doi:10.1016/j.clgc.2016.08.005. Miaris N, Maltezou M, Papaxoinis G, et al. Posterior reversible encephalopathy syndrome with concurrent nephrotic syndrome in a patient treated with pazopanib for metastatic renal cell carcinoma: case report and review of the literature. Clin Genitourin Cancer. 2017; doi:10.​1016/​j.​clgc.​2016.​08.​005.
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go back to reference How J, Blattner M, Fowler S, et al. Chemotherapy-associated posterior reversible encephalopathy syndrome: a case report and review of the literature. Neurologist 2016;21(6):112–7. doi:10.1097/NRL.0000000000000105. How J, Blattner M, Fowler S, et al. Chemotherapy-associated posterior reversible encephalopathy syndrome: a case report and review of the literature. Neurologist 2016;21(6):112–7. doi:10.​1097/​NRL.​0000000000000105​.
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go back to reference Myint ZW, Sen JM, Watts NL, et al. Reversible posterior leukoencephalopathy syndrome during regorafenib treatment: a case report and literature Review of reversible posterior leukoencephalopathy syndrome associated with multikinase inhibitors. Clin Colorectal Cancer. 2017;13(2):127–30. doi:10.1016/j.clcc.2013.12.003.CrossRef Myint ZW, Sen JM, Watts NL, et al. Reversible posterior leukoencephalopathy syndrome during regorafenib treatment: a case report and literature Review of reversible posterior leukoencephalopathy syndrome associated with multikinase inhibitors. Clin Colorectal Cancer. 2017;13(2):127–30. doi:10.​1016/​j.​clcc.​2013.​12.​003.CrossRef
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go back to reference Chen H, Modiano MR, Neal JW, et al. A phase II multicentre study of ziv-aflibercept in combination with cisplatin and pemetrexed in patients with previously untreated advanced/metastatic non-squamous non-small cell lung cancer. Br J Cancer. 2014;110(3):602–8. doi:10.1038/bjc.2013.735.CrossRefPubMed Chen H, Modiano MR, Neal JW, et al. A phase II multicentre study of ziv-aflibercept in combination with cisplatin and pemetrexed in patients with previously untreated advanced/metastatic non-squamous non-small cell lung cancer. Br J Cancer. 2014;110(3):602–8. doi:10.​1038/​bjc.​2013.​735.CrossRefPubMed
19.
Metadata
Title
Posterior Reversible Encephalopathy Syndrome During Treatment with Aflibercept, 5-Fluorouracil, Leucovorin, and Irinotecan for Metastatic Colorectal Cancer
Authors
Nikolaos Miaris
Joseph Sgouros
Margarita Gerolympou
Basilios Spyropoulos
Dionysios Drakopoulos
Stefania Gkoura
Helen Res
Epaminondas Samantas
Publication date
01-03-2019
Publisher
Springer US
Published in
Journal of Gastrointestinal Cancer / Issue 1/2019
Print ISSN: 1941-6628
Electronic ISSN: 1941-6636
DOI
https://doi.org/10.1007/s12029-017-9986-x

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