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Journal of Gastrointestinal Cancer
Published in: Journal of Gastrointestinal Cancer 1/2011

01-03-2011 | Letter to the Editor

A First Reported Case of Dedifferentiated Liposarcoma of the Esophagus with Molecular Diagnosis

Authors: Emmanuel Watkin, Mojgan Devouassoux-Shisheboran, Florence Pedeutour, Pauline Lagarde, Monique Salle, Dominique Ranchère-Vince, Jacques Baulieux, Raphaëlle Barnoud

Published in: Journal of Gastrointestinal Cancer | Issue 1/2011

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Excerpt

Liposarcoma is one of the most common soft tissue sarcomas in adults but is rarely seen in the gastrointestinal tract, especially in the esophagus. Since the first description of primary liposarcoma of the esophagus in 1983 by Mansour et al. [1], around 20 cases have been reported in the English literature. We describe herein, the first case of dedifferentiated liposarcoma (DDLPS) of the esophagus. This diagnosis was based on MDM2 and CDK4 immunoexpression and molecular analysis. …
Literature
1.
Mansour KA, Fritz RC, Jacobs DM, Vellios F. Pedunculated liposarcoma of the esophagus: a first case report. J Thorac Cardiovasc Surg. 1983;86(3):447–50.PubMed
2.
Chibon F, Mariani O, Derré J, Malinge S, Coindre JM, Guillou L, et al. A subgroup of malignant fibrous histiocytomas is associated with genetic changes similar to those of well-differentiated liposarcomas. Cancer Genet Cytogenet. 2002;139(1):24–9.CrossRefPubMed
3.
Binh MB, Sastre-Garau X, Guillou L, de Pinieux G, Terrier P, Lagacé R, et al. MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol. 2005;29(10):1340–7.CrossRefPubMed
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Hostein I, Pelmus M, Aurias A, Pedeutour F, Mathoulin-Pélissier S, Coindre JM. Evaluation of MDM2 and CDK4 amplification by real-time PCR on paraffin wax-embedded material: a potential tool for the diagnosis of atypical lipomatous tumours/well-differentiated liposarcomas. J Pathol. 2004;202(1):95–102.CrossRefPubMed
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Sirvent N, Coindre JM, Maire G, Hostein I, Keslair F, Guillou L, et al. Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. Am J Surg Pathol. 2007;31(10):1476–89.CrossRefPubMed
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Jakowski JD, Wakely Jr PE. Rhabdomyomatous well-differentiated liposarcoma arising in giant fibrovascular polyp of the esophagus. Ann Diagn Pathol. 2009;13(4):263–8.CrossRefPubMed
Metadata
Title
A First Reported Case of Dedifferentiated Liposarcoma of the Esophagus with Molecular Diagnosis
Authors
Emmanuel Watkin
Mojgan Devouassoux-Shisheboran
Florence Pedeutour
Pauline Lagarde
Monique Salle
Dominique Ranchère-Vince
Jacques Baulieux
Raphaëlle Barnoud
Publication date
01-03-2011
Publisher
Springer US
Published in
Journal of Gastrointestinal Cancer / Issue 1/2011
Print ISSN: 1941-6628
Electronic ISSN: 1941-6636
DOI
https://doi.org/10.1007/s12029-010-9174-8

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