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Open Access 01-10-2019 | Vasculitis | Interpretive Synthesis Review Article

The epipharynx-kidney axis triggers glomerular vasculitis in immunoglobulin A nephropathy

Authors: Osamu Hotta, Takashi Oda

Published in: Immunologic Research | Issue 4-5/2019

Abstract

Macroscopic hematuria concomitant with acute pharyngitis is a characteristic feature of immunoglobulin A nephropathy (IgAN). Although the underlying mechanism of worsening hematuria has not been fully elucidated, activation of the innate immune system of nasopharynx-associated lymphoid tissue is thought to play an important role. The epipharynx is an immunologically activated site even under normal conditions, and enhanced activation of innate immunity is likely to occur in response to airborne infection. As latent but significant epipharyngitis presents in most IgAN patients, it is plausible that acute pharyngitis due to airway infection may contribute as a trigger of the epipharyngeal innate immune system, which is already upregulated in the chronically inflamed environment. The aim of this review was to discuss the mechanism of epipharynx-kidney axis involvement in glomerular vasculitis responsible for the worsening of hematuria in IgAN.

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Title: The epipharynx-kidney axis triggers glomerular vasculitis in immunoglobulin A nephropathy
Authors: Osamu Hotta
Takashi Oda
Publication date: 01-10-2019
Publisher: Springer US
Keywords: Vasculitis
Pharyngitis
Vasculitis
Hematuria
Cytokines
Pharyngitis
Published in: Immunologic Research / Issue 4-5/2019
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-019-09099-3

ACC 2024 Congress

Springer Medicine

The epipharynx-kidney axis triggers glomerular vasculitis in immunoglobulin A nephropathy

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

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