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01-10-2017 | Interpretive Synthesis Review Article

Signaling interactions predicted by the Tritope model of the TCR

Author: Melvin Cohn

Published in: Immunologic Research | Issue 5/2017

Abstract

As the data accumulates, it becomes obvious that the Standard Model of TCR structure-function relationships is in jeopardy. The proposed Tritope model has become more meaningful and, in any case, is richer in prediction and explanation. This is illustrated here by using the signaling interactions of the TCR as examples. An unsuspected signaling pathway for positive selection, and for alloreactivity, is predicted. Further, crucial data needed to elucidate the structural elements that distinguish signaling for restrictive- versus allo-reactivity are identified.

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Title: Signaling interactions predicted by the Tritope model of the TCR
Author: Melvin Cohn
Publication date: 01-10-2017
Publisher: Springer US
Published in: Immunologic Research / Issue 5/2017
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-017-8941-z

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Signaling interactions predicted by the Tritope model of the TCR

Abstract

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