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Immunologic Research
Published in: Immunologic Research 1-3/2012

01-12-2012 | Immunology at Mount Sinai

The influence of pregnancy on systemic immunity

Authors: Michael Pazos, Rhoda S. Sperling, Thomas M. Moran, Thomas A. Kraus

Published in: Immunologic Research | Issue 1-3/2012

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Abstract

Adaptations in maternal systemic immunity are presumed to be responsible for observed alterations in disease susceptibility and severity as pregnancy progresses. Epidemiological evidence as well as animal studies have shown that influenza infections are more severe during the second and third trimesters of pregnancy, resulting in greater morbidity and mortality, although the reason for this is still unclear. Our laboratory has taken advantage of 20 years of experience studying the murine immune response to respiratory viruses to address questions of altered immunity during pregnancy. With clinical studies and unique animal model systems, we are working to define the mechanisms responsible for altered immune responses to influenza infection during pregnancy and what roles hormones such as estrogen or progesterone play in these alterations.
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Metadata
Title
The influence of pregnancy on systemic immunity
Authors
Michael Pazos
Rhoda S. Sperling
Thomas M. Moran
Thomas A. Kraus
Publication date
01-12-2012
Publisher
Springer-Verlag
Published in
Immunologic Research / Issue 1-3/2012
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-012-8303-9

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