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01-12-2017

MEN2 Syndrome-Related Medullary Thyroid Carcinoma with Focal Tyrosine Hydroxylase Expression: Does It Represent a Hybrid Cellular Phenotype or Functional State of Tumor Cells?

Authors: Ozgur Mete, Ahmed Essa, Anil Bramdev, Navendren Govender, Runjan Chetty

Published in: Endocrine Pathology | Issue 4/2017

Excerpt

A 38-year-old woman presented with abdominal pain, right-sided large thyroid mass with dysphagia, lower backache, and weight gain. During the clinical examination, she was pale and was found to have hypertension. The initial laboratory testing showed a normal thyroid function along with low hemoglobin (7.6 g/dl, normal: 12–15 g/dl). Ultrasound identified a large thyroid mass occupying almost the entire right lobe. No cervical lymphadenopathy was detected. A fine needle-aspiration biopsy of the thyroid mass was scheduled; however, the patient opted for total thyroidectomy given her elevated calcitonin (19930 ng/l; normal: 0–5 ng/l) and CEA (1425 ng/ml; normal: 0–5 ng/ml) levels. …

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Mete O, Tischler AS, de Krijger R, McNicol AM, Eisenhofer G, Pacak K, Ezzat S, Asa SL. Protocol for the examination of specimens from patients with pheochromocytomas and extra-adrenal paragangliomas. Arch Pathol Lab Med. 138:182–188, 2014.CrossRefPubMedPubMedCentral

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Title: MEN2 Syndrome-Related Medullary Thyroid Carcinoma with Focal Tyrosine Hydroxylase Expression: Does It Represent a Hybrid Cellular Phenotype or Functional State of Tumor Cells?
Authors: Ozgur Mete
Ahmed Essa
Anil Bramdev
Navendren Govender
Runjan Chetty
Publication date: 01-12-2017
Publisher: Springer US
Published in: Endocrine Pathology / Issue 4/2017
Print ISSN: 1046-3976
Electronic ISSN: 1559-0097
DOI: https://doi.org/10.1007/s12022-017-9485-4

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