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01-12-2010

Primary Sellar Neuroblastoma Presenting with Syndrome of Inappropriate Secretion of Anti-diuretic Hormone

Authors: Bishan Radotra, Vasileios Apostolopoulos, Ann Sandison, Emma C. I. Hatfield, Nigel Mendoza, Jill Moss, Amrish Mehta, Mark Glaser, Karim Meeran, Federico Roncaroli

Published in: Endocrine Pathology | Issue 4/2010

Abstract

A 29-year-old Ethiopian man presented with marked bilateral visual loss, headache, hypopituitarism and significant hyponatraemia (115 mmol/L). A brain MRI scan demonstrated a large, lobulated, sellar and suprasellar mass, elevating the floor of the 3rd ventricle and compressing the optic chiasm. The patient underwent a transphenoidal resection of the mass followed by a craniotomy 10 days later. Histological examination demonstrated a Hyams’ grade III neuroblastoma with ectopic expression of vasopressin. He underwent fractionated radiotherapy at a dose of 60 Gy in 30 fractions. Fourteen months after the onset, he is well with no neuroimaging evidence of tumour recurrence. His serum and urine sodium are completely normalised.

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Title: Primary Sellar Neuroblastoma Presenting with Syndrome of Inappropriate Secretion of Anti-diuretic Hormone
Authors: Bishan Radotra
Vasileios Apostolopoulos
Ann Sandison
Emma C. I. Hatfield
Nigel Mendoza
Jill Moss
Amrish Mehta
Mark Glaser
Karim Meeran
Federico Roncaroli
Publication date: 01-12-2010
Publisher: Springer US
Published in: Endocrine Pathology / Issue 4/2010
Print ISSN: 1046-3976
Electronic ISSN: 1559-0097
DOI: https://doi.org/10.1007/s12022-010-9140-9

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