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Endocrine

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01-01-2021 | Meta-Analysis

Meta-analysis of metabolic changes in children with idiopathic growth hormone deficiency after recombinant human growth hormone replacement therapy

Authors: Yuan Yuan, Bo Zhou, Shufang Liu, Yunfeng Wang, Kundi Wang, Zhixin Zhang, Wenquan Niu

Published in: Endocrine | Issue 1/2021

Abstract

Purposes

We aimed to assess the effects of recombinant human growth hormone (rhGH) replacement therapy on metabolic changes by synthesizing data from clinical trials involving children with idiopathic growth hormone deficiency (IGHD).

Methods

Two investigators independently completed literature search, quality assessment, and data extraction. Effect-size estimates are expressed as weighted mean difference (WMD) with 95% confidence interval (CI).

Results

A total of 16 clinical trials involving 1319 children were eligible for analysis. Overall analyses showed that total cholesterol was significantly decreased after rhGH replacement therapy (WMD: −0.20 mmol/l; 95% CI: −0.30 to −0.10; p < 0.001), and high-density lipoprotein was significantly increased (WMD: 0.29 mmol/l; 95% CI: 0.24 to 0.33; p < 0.001). Marginal increase was noted for low-density lipoprotein (WMD: −0.22 mmol/l; 95% CI: −0.47 to 0.22; p = 0.092). Subsidiary and meta-regression analyses revealed that length of intervention and sample size were possible causes of heterogeneity. There was a low probability of publication bias.

Conclusions

Our findings indicate an obviously favorable role of rhGH replacement therapy in lipid metabolism in children with IGHD, and this role might be dependent on length of intervention.

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Title: Meta-analysis of metabolic changes in children with idiopathic growth hormone deficiency after recombinant human growth hormone replacement therapy
Authors: Yuan Yuan
Bo Zhou
Shufang Liu
Yunfeng Wang
Kundi Wang
Zhixin Zhang
Wenquan Niu
Publication date: 01-01-2021
Publisher: Springer US
Published in: Endocrine / Issue 1/2021
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-020-02435-w

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Meta-analysis of metabolic changes in children with idiopathic growth hormone deficiency after recombinant human growth hormone replacement therapy

Abstract

Purposes

Methods

Results

Conclusions

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Abstract

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