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Endocrine
Published in: Endocrine 2/2020

Open Access 01-05-2020 | Thyroid Disease | Viewpoint

Autoimmune thyroid disease

Author: Anthony Weetman

Published in: Endocrine | Issue 2/2020

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Excerpt

I have been asked to give a brief summary of my perspective on the initial development of research in autoimmune thyroid disease and Marian Ludgate’s contribution to that, as well as outlining thoughts on future progress in the field. This is therefore a personal article which commemorates our time together in Cardiff in the 1980s that has led to a very enjoyable and fruitful collaboration over three decades. A detailed review is available elsewhere of the early period of thyroid research [1] and only minimal references are contained in this article. …
Literature
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A.P. Weetman, A.M. McGregor, Autoimmune thyroid disease: developments in our understanding. Endocr. Rev. 5, 309–355 (1984)CrossRef
2.
N.R. Rose, E. Witebsky, Studies in organ specificity. V. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts. J. Immunol. 76, 417–427 (1956)PubMed
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P.N. Campbell, D. Doniach, R.V. Hudson, I.M. Roitt, Auto-antibodies in Hashimoto’s disease (lymphadenoid goitre). Lancet 271, 820–821 (1956)PubMed
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R. Hall, S.G. Owen, G.A. Smart, Evidence for genetic predisposition to formation of thyroid autoantibodies. Lancet 276, 187–188 (1960)CrossRef
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N.R. Rose, The genetics of autoimmune thyroiditis: the first decade. J. Autoimmun. 37, 88–94 (2011)CrossRef
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M. ElRehewy, Y.M. Kong, A.A. Giraldo, N.R. Rose, Syngeneic thyroglobulin is immunogenic in good responder mice. Eur. J. Immunol. 11, 146–151 (1981)CrossRef
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R. Volpé, The immunoregulatory disturbance in autoimmune thyroid disease. Autoimmun 2, 55–72 (1988)CrossRef
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W.J. Penhale, W.J. Irvine, J.R. Inglis, A. Farmer, Thyroiditis in T cell-depleted rats: suppression of the autoallergic response by reconstitution with normal lymphoid cells. Clin. Exp. Immunol. 25, 6–16 (1976)PubMedPubMedCentral
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M.E. Ludgate, A.M. McGregor, A.P. Weetman, S. Ratanachaiyavong, J.H. Lazarus, R. Hall, G.W. Middleton, Analysis of T cell subsets in Graves’ disease: alterations associated with carbimazole. Brit. Med. J. 288, 526–530 (1984)CrossRef
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M.E. Ludgate, S. Ratanachaiyavong, A.P. Weetman, R. Hall, A.M. McGregor, Failure to demonstrate cell-mediated immune responses to thyroid antigens in Graves’ disease using in vitro assays of lymphokine-mediated migration inhibition. J. Clin. Endocrinol. Metab. 60, 98–102 (1985)CrossRef
Metadata
Title
Autoimmune thyroid disease
Author
Anthony Weetman
Publication date
01-05-2020
Publisher
Springer US
Published in
Endocrine / Issue 2/2020
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-020-02188-6

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