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01-10-2019 | Levothyroxine | Review

Novel thyroxine formulations: a further step toward precision medicine

Authors: Camilla Virili, Pierpaolo Trimboli, Marco Centanni

Published in: Endocrine | Issue 1/2019

Abstract

Levothyroxine (T4) is a critical-dose drug, because little variations in the blood concentration may cause treatment failure as well as iatrogenic thyrotoxicosis. Despite the dose response of this drug being more carefully titrated nowadays, several papers still report that a significant fraction of patients treated with levothyroxine demonstrate a TSH which is not on target. Moreover, some widespread gastrointestinal disorders as well as interfering drugs and foods may cause the “refractoriness” of a significant number of patients to an expected dose of thyroxine. The increasing awareness of the mechanisms interfering with the oral thyroid hormone bioavailability and the body of evidence regarding the complexity of treatment in certain classes of patients prompted pharmaceutical research to identify new hormonal formulations to optimize the performance of this drug. In this brief review, the progression of the scientific knowledge of novel T4 formulations use has been analyzed.

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Title: Novel thyroxine formulations: a further step toward precision medicine
Authors: Camilla Virili
Pierpaolo Trimboli
Marco Centanni
Publication date: 01-10-2019
Publisher: Springer US
Keyword: Levothyroxine
Published in: Endocrine / Issue 1/2019
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-019-02049-x

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