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01-01-2019 | Research Letter

Gonadotropin replacement in male thalassemia major patients with arrested puberty and acquired hypogonadotropic hypogonadism (AAH): preliminary results and potential factors affecting induction of spermatogenesis

Authors: Vincenzo De Sanctis, Ashraf T. Soliman, Duran Canatan, Salvatore Di Maio, Heba Elsedfy, Alaa Baioumi, Christos Kattamis

Published in: Endocrine | Issue 1/2019

Excerpt

Although spontaneous fertility can occur in well-transfused and well-chelated patients, with β-thalassemia major (β-ΤΜ), the majority are sub fertile due to hypogonadotropic hypogonadism (HH), secondary to transfusional haemosiderosis [1]. Ιn several studies, 40 to 80% of β-ΤΜ patients reported to have arrested puberty, pubertal failure, sexual dysfunction, and infertility [1, 2]. …

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Title: Gonadotropin replacement in male thalassemia major patients with arrested puberty and acquired hypogonadotropic hypogonadism (AAH): preliminary results and potential factors affecting induction of spermatogenesis
Authors: Vincenzo De Sanctis
Ashraf T. Soliman
Duran Canatan
Salvatore Di Maio
Heba Elsedfy
Alaa Baioumi
Christos Kattamis
Publication date: 01-01-2019
Publisher: Springer US
Published in: Endocrine / Issue 1/2019
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-018-1772-4

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