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01-03-2019 | Insulins | Original Article

Effects of growth hormone on hepatic insulin sensitivity and glucose effectiveness in healthy older adults

Authors: Lala Forrest, Caroline Sedmak, Shanaz Sikder, Shivraj Grewal, S. Mitchell Harman, Marc R. Blackman, Ranganath Muniyappa

Published in: Endocrine | Issue 3/2019

Abstract

Purpose

Growth hormone (GH) replacement decreases insulin sensitivity in healthy individuals. However, the effects of GH on organ-specific insulin sensitivity and glucose effectiveness are not well characterized. The purpose of this study was to evaluate the effects of GH administration for 26 weeks on muscle and hepatic insulin sensitivity and glucose effectiveness in healthy older individuals.

Methods

This report is from a 26-week randomized, double-blind, placebo-controlled parallel-group trial in healthy, ambulatory, community-dwelling older women and men. We compared surrogate indices of insulin sensitivity [quantitative insulin-sensitivity check index (QUICKI), muscle insulin sensitivity index (MISI), hepatic insulin resistance index (HIRI)] and glucose effectiveness [oral glucose effectiveness index (oGE)] derived from oral glucose tolerance tests (OGTTs) in subjects before and after 26 weeks of administration of GH (n = 17) or placebo (n = 15) as an exploratory outcome.

Results

GH administration for 26 weeks significantly increased fasting insulin concentrations and HIRI but did not significantly change MISI or oGE compared to placebo.

Conclusions

GH administration for 26 weeks in healthy older subjects impairs insulin sensitivity in the liver but not skeletal muscle and does not alter glucose effectiveness.

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Title: Effects of growth hormone on hepatic insulin sensitivity and glucose effectiveness in healthy older adults
Authors: Lala Forrest
Caroline Sedmak
Shanaz Sikder
Shivraj Grewal
S. Mitchell Harman
Marc R. Blackman
Ranganath Muniyappa
Publication date: 01-03-2019
Publisher: Springer US
Keywords: Insulins
Insulins
Published in: Endocrine / Issue 3/2019
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-018-01834-4

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