Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Endocrine
Published in: Endocrine 1/2016

01-07-2016 | Editorial

Reassessing the grade of gastroenteropancreatic neuroendocrine neoplasms

Author: David S. Klimstra

Published in: Endocrine | Issue 1/2016

Login to get access

Excerpt

In the study by Grillo et al. [1], the authors undertook systematic re-evaluation of gastroenteropancreatic neuroendocrine neoplasms diagnosed before formal grading and staging were routinely performed. They found that reclassification was feasible and of value, as the outcome of the patients strongly correlated with the grade, using the ENETS/WHO grading system. …
Literature
1.
2.
W.D. Travis et al., Neuroendocrine tumors of the lung with proposed criteria for large-cell neuroendocrine carcinoma. An ultrastructural, immunohistochemical, and flow cytometric study of 35 cases. Am. J. Surg. Pathol. 15(6), 529–553 (1991)CrossRefPubMed
3.
S.N. Hochwald et al., Prognostic factors in pancreatic endocrine neoplasms: an analysis of 136 cases with a proposal for low-grade and intermediate-grade groups. J. Clin. Oncol. 20(11), 2633–2642 (2002)CrossRefPubMed
4.
S. Van Eeden et al., Classification of low-grade neuroendocrine tumors of midgut and unknown origin. Hum. Pathol. 33(11), 1126–1132 (2002)CrossRefPubMed
5.
D.S. Klimstra, Pathologic classification of neuroendocrine neoplasms. Hematol. Oncol. Clin. North Am. 30(1), 1–19 (2016)CrossRefPubMed
6.
A. Scarpa et al., Pancreatic endocrine tumors: improved TNM staging and histopathological grading permit a clinically efficient prognostic stratification of patients. Mod. Pathol. 23(6), 824–833 (2010)CrossRefPubMed
7.
D.S. Klimstra et al., Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data set. Am. J. Surg. Pathol. 34(3), 300–313 (2010)CrossRefPubMed
8.
Z. Yang, L.H. Tang, D.S. Klimstra, Effect of tumor heterogeneity on the assessment of Ki67 labeling index in well-differentiated neuroendocrine tumors metastatic to the liver: implications for prognostic stratification. Am. J. Surg. Pathol. 35(6), 853–860 (2011)CrossRefPubMed
9.
V. Rebours et al., Can pancreatic neuroendocrine tumour biopsy accurately determine pathological characteristics? Dig. Liver Dis. 47(11), 973–977 (2015)CrossRefPubMed
10.
N. Raj, D. Reidy-Lagunes, Systemic therapies for advanced pancreatic neuroendocrine tumors. Hematol. Oncol. Clin. North Am. 30(1), 119–133 (2016)CrossRefPubMed
11.
O. Basturk et al., The high-grade (WHO G3) pancreatic neuroendocrine tumor category is morphologically and biologically heterogenous and includes both well differentiated and poorly differentiated neoplasms. Am. J. Surg. Pathol. 39(5), 683–690 (2015)CrossRefPubMedPubMedCentral
12.
L.H. Tang et al., Well-differentiated neuroendocrine tumors with a morphologically apparent high-grade component: a pathway distinct from poorly differentiated neuroendocrine carcinomas. Clin. Cancer Res. 22(4), 1011–1017 (2015)CrossRefPubMed
13.
H. Sorbye et al., Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3): the NORDIC NEC study. Ann. Oncol. 24(1), 152–160 (2013)CrossRefPubMed
Metadata
Title
Reassessing the grade of gastroenteropancreatic neuroendocrine neoplasms
Author
David S. Klimstra
Publication date
01-07-2016
Publisher
Springer US
Published in
Endocrine / Issue 1/2016
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-016-0966-x

Other articles of this Issue 1/2016

Endocrine 1/2016 Go to the issue

Original Article

Combined use of conventional smear and liquid-based preparation versus conventional smear for thyroid fine-needle aspiration

Original Article

Effect of pasireotide on glucose- and growth hormone-related biomarkers in patients with inadequately controlled acromegaly

Original Article

Long-term effects of growth hormone (GH) replacement therapy on hematopoiesis in a large cohort of children with GH deficiency

Original Article

mTORC1 pathway mediates beta cell compensatory proliferation in 60 % partial-pancreatectomy mice

Endocrine Methods and Techniques

Twenty years of gastroenteropancreatic neuroendocrine tumors: is reclassification worthwhile and feasible?

Review

Management of hereditary medullary thyroid carcinoma

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits