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01-07-2016 | Original Article

Association of cord blood des-acyl ghrelin with birth weight, and placental GHS-R1 receptor expression in SGA, AGA, and LGA newborns

Authors: Martha I. González-Domínguez, Maria-Luisa Lazo-de-la-Vega-Monroy, Silvio Zaina, Myrna Sabanero, Leonel Daza-Benítez, Juan Manuel Malacara, Gloria Barbosa-Sabanero

Published in: Endocrine | Issue 1/2016

Abstract

Although ghrelin in cord blood has been associated to birth weight, its role in fetal and postnatal growth has not been elucidated. The aim of this study was to analyze total ghrelin, acyl ghrelin (AG), and des-acyl ghrelin (DAG) in cord blood of newborns with idiopathic birth weight alterations, and to evaluate protein expression of placental GHS-R1, in order to investigate their correlation with birth weight and placental weight. We performed a cross-sectional comparative study in umbilical cord blood and placentas from healthy mothers of SGA, AGA, and LGA (small, adequate and large for gestational age) term newborns (n = 20 per group). Cord blood total ghrelin, AG, and DAG were measured by ELISA, and placental GHS-R1 expression was evaluated by Western blot. Cord blood DAG was higher in SGA compared to AGA newborns (902.1 ± 109.1 and 597.4 ± 58.2 pg/ml, respectively, p = 0.01) while LGA and AGA showed similar values (627.2 ± 76.4 pg/ml for LGA, p = 0.80). DAG negatively correlated with birthweight (r = −0.31, p = 0.02) and placental weight (r = −0.33, p = 0.02). No differences in AG or total ghrelin were found. GHS-R1 protein in placenta was not differentially expressed among SGA, AGA, and LGA. Our results suggest a role of DAG in intrauterine growth. Further studies are needed in order to elucidate the mechanisms by which DAG participates in fetal growth.

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Title: Association of cord blood des-acyl ghrelin with birth weight, and placental GHS-R1 receptor expression in SGA, AGA, and LGA newborns
Authors: Martha I. González-Domínguez
Maria-Luisa Lazo-de-la-Vega-Monroy
Silvio Zaina
Myrna Sabanero
Leonel Daza-Benítez
Juan Manuel Malacara
Gloria Barbosa-Sabanero
Publication date: 01-07-2016
Publisher: Springer US
Published in: Endocrine / Issue 1/2016
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-015-0833-1

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Bone resorption following weight loss surgery is associated with treatment procedure and changes in secreted Wnt antagonists

Non-functioning pituitary adenomas: growth and aggressiveness

Serum but not salivary cortisol levels are influenced by daily glycemic oscillations in type 2 diabetes

Blood glucose fluctuation accelerates renal injury involved to inhibit the AKT signaling pathway in diabetic rats

Twenty years of gastroenteropancreatic neuroendocrine tumors: is reclassification worthwhile and feasible?

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page