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Published in: Endocrine 3/2016

01-09-2016 | Viewpoint

Statin reduces orbitopathy risk in patients with Graves’ disease by modulating apoptosis and autophagy activities

Authors: Maurizio Bifulco, Elena Ciaglia

Published in: Endocrine | Issue 3/2016

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Abstract

Statins use has been associated with reduced risk for developing orbitopathy among patients with Graves’ disease. We hypothesize that statin reduces orbitopathy risk mainly by modulating both apoptosis and autophagy activities in patients with Graves’ disease.
Literature
1.
go back to reference J.M. Hershman, Statins and thyroidectomy may reduce the risk of orbitopathy developing in patients with Graves’ disease. Clin. Thyroidol. 27, 32–33 (2015)CrossRef J.M. Hershman, Statins and thyroidectomy may reduce the risk of orbitopathy developing in patients with Graves’ disease. Clin. Thyroidol. 27, 32–33 (2015)CrossRef
2.
go back to reference J.D. Stein, D. Childers, S. Gupta, N. Talwar, B. Nan, B.J. Lee, T.J. Smith, R. Douglas, Risk factors for developing thyroid-associated ophthalmopathy among individuals with Graves disease. JAMA Ophthalmol. 133, 290–296 (2015)CrossRefPubMedPubMedCentral J.D. Stein, D. Childers, S. Gupta, N. Talwar, B. Nan, B.J. Lee, T.J. Smith, R. Douglas, Risk factors for developing thyroid-associated ophthalmopathy among individuals with Graves disease. JAMA Ophthalmol. 133, 290–296 (2015)CrossRefPubMedPubMedCentral
3.
go back to reference A. Kawashima, K. Tanigawa, T. Akama, A. Yoshihara, N. Ishii, K. Suzuki, Innate immune activation and thyroid autoimmunity. J. Clin. Endocrinol. Metab. 96, 3661–3671 (2011)CrossRefPubMed A. Kawashima, K. Tanigawa, T. Akama, A. Yoshihara, N. Ishii, K. Suzuki, Innate immune activation and thyroid autoimmunity. J. Clin. Endocrinol. Metab. 96, 3661–3671 (2011)CrossRefPubMed
4.
go back to reference J.S. Yoon, H.J. Lee, M.K. Chae, E.J. Lee, Autophagy is involved in the initiation and progression of Graves’ orbitopathy. Thyroid 25, 445–454 (2015)CrossRefPubMed J.S. Yoon, H.J. Lee, M.K. Chae, E.J. Lee, Autophagy is involved in the initiation and progression of Graves’ orbitopathy. Thyroid 25, 445–454 (2015)CrossRefPubMed
5.
go back to reference M.C. Maiuri, E. Zalckvar, A. Kimchi, G. Kroemer, Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 8(9), 741–752 (2007)CrossRefPubMed M.C. Maiuri, E. Zalckvar, A. Kimchi, G. Kroemer, Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 8(9), 741–752 (2007)CrossRefPubMed
6.
go back to reference O. Konuk, A. Hondur, N. Akyurek, M. Unal, Apoptosis in orbital fibroadipose tissue and its association with clinical features in Graves’ ophthalmopathy. Ocular Immunol. Inflamm. 15, 105–111 (2007)CrossRef O. Konuk, A. Hondur, N. Akyurek, M. Unal, Apoptosis in orbital fibroadipose tissue and its association with clinical features in Graves’ ophthalmopathy. Ocular Immunol. Inflamm. 15, 105–111 (2007)CrossRef
7.
go back to reference M. Thurnher, O. Nussbaumer, G. Gruenbacher, Novel aspects of mevalonate pathway inhibitors as antitumor agents. Clin. Cancer Res. 18(13), 3524–3531 (2012)CrossRefPubMed M. Thurnher, O. Nussbaumer, G. Gruenbacher, Novel aspects of mevalonate pathway inhibitors as antitumor agents. Clin. Cancer Res. 18(13), 3524–3531 (2012)CrossRefPubMed
8.
go back to reference S. Ghavami, B. Yeganeh, G.L. Stelmack, H.H. Kashani, P. Sharma, R. Cunnington, S. Rattan, K. Bathe, T. Klonisch, I.M. Dixon, D.H. Freed, A.J. Halayko, Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts. Cell Death Dis. 3, e330 (2012)CrossRefPubMedPubMedCentral S. Ghavami, B. Yeganeh, G.L. Stelmack, H.H. Kashani, P. Sharma, R. Cunnington, S. Rattan, K. Bathe, T. Klonisch, I.M. Dixon, D.H. Freed, A.J. Halayko, Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts. Cell Death Dis. 3, e330 (2012)CrossRefPubMedPubMedCentral
9.
go back to reference M.J. Shih, S.L. Liao, K.T. Kuo, T.J. Smith, L.M. Chuang, Molecular pathology of Muller’s muscle in Graves’ ophthalmopathy. J. Clin. Endocrinol. Metab. 91(3), 1159–1167 (2006)CrossRefPubMed M.J. Shih, S.L. Liao, K.T. Kuo, T.J. Smith, L.M. Chuang, Molecular pathology of Muller’s muscle in Graves’ ophthalmopathy. J. Clin. Endocrinol. Metab. 91(3), 1159–1167 (2006)CrossRefPubMed
10.
go back to reference V. Croons, I. De Meyer, S.M. Houten, W. Martinet, H. Bult, A.G. Herman, G.R. De Meyer, Effect of statins on the viability of macrophages and smooth muscle cells. J. Cardiovasc. Pharmacol. 55(3), 269–275 (2010)CrossRefPubMed V. Croons, I. De Meyer, S.M. Houten, W. Martinet, H. Bult, A.G. Herman, G.R. De Meyer, Effect of statins on the viability of macrophages and smooth muscle cells. J. Cardiovasc. Pharmacol. 55(3), 269–275 (2010)CrossRefPubMed
11.
go back to reference E.H. Lai, C.Y. Hong, S.H. Kok, K.L. Hou, L.H. Chao, L.D. Lin, M.H. Chen, P.H. Wu, S.K. Lin, Simvastatin alleviates the progression of periapical lesions by modulating autophagy and apoptosis in osteoblasts. J. Endod. 38, 757–763 (2012)CrossRefPubMed E.H. Lai, C.Y. Hong, S.H. Kok, K.L. Hou, L.H. Chao, L.D. Lin, M.H. Chen, P.H. Wu, S.K. Lin, Simvastatin alleviates the progression of periapical lesions by modulating autophagy and apoptosis in osteoblasts. J. Endod. 38, 757–763 (2012)CrossRefPubMed
12.
go back to reference S. Ghavami, M.M. Mutawe, P. Sharma, B. Yeganeh, K.D. McNeill, T. Klonisch, H. Unruh, H.H. Kashani, D. Schaafsma, M. Los, A.J. Halayko, Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. PLoS One 6, e16523 (2011)CrossRefPubMedPubMedCentral S. Ghavami, M.M. Mutawe, P. Sharma, B. Yeganeh, K.D. McNeill, T. Klonisch, H. Unruh, H.H. Kashani, D. Schaafsma, M. Los, A.J. Halayko, Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. PLoS One 6, e16523 (2011)CrossRefPubMedPubMedCentral
Metadata
Title
Statin reduces orbitopathy risk in patients with Graves’ disease by modulating apoptosis and autophagy activities
Authors
Maurizio Bifulco
Elena Ciaglia
Publication date
01-09-2016
Publisher
Springer US
Published in
Endocrine / Issue 3/2016
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-015-0762-z

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