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Endocrine
Published in: Endocrine 3/2015

01-12-2015 | Endocrine Imaging

Preoperative localization of adult nesidioblastosis using 68Ga-DOTA-exendin-4-PET/CT

Authors: Emanuel Christ, Damian Wild, Kwadwo Antwi, Beatrice Waser, Melpomeni Fani, Stefanie Schwanda, Tobias Heye, Christoph Schmid, Hans Ulrich Baer, Aurel Perren, Jean Claude Reubi

Published in: Endocrine | Issue 3/2015

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Excerpt

The term “nesidioblastosis” has been used to denote histopathological findings such as neogenesis from pancreatic ductal epithelium in parallel with β-cell hyperplasia and hypertrophy (1). This entity was first described in children and neonates and is characterized by endogenous hyperinsulinemic hypoglycemia. The incidence rate in adults ranges between 0.5 and 7 %. The pathophysiological mechanisms in adults are ill-defined. …
Literature
1.
M. Anlauf, D. Wieben, A. Perren, B. Sipos, P. Komminoth, A. Raffel, M.L. Kruse, C. Fottner, W.T. Knoefel, H. Monig, P.U. Heitz, G. Kloppel, Persistent hyperinsulinemic hypoglycemia in 15 adults with diffuse nesidioblastosis: diagnostic criteria, incidence, and characterization of beta-cell changes. Am. J. Surg. Pathol. 29, 524–533 (2005)CrossRefPubMed
2.
E. Christ, D. Wild, S. Ederer, M. Béhé, G. Nicolas, M. Caplin, M. Brändle, T. Clerici, S. Fischli, C. Stettler, P. Ell, J. Seufert, B. Gloor, A. Perren, J.C. Reubi, F. Forrer, Glucagon-like peptide-1 receptor imaging for the localisation of insulinomas: a prospective multicentre imaging study. Lancet Diabetes Endocrinol 1, 115–122 (2013)CrossRefPubMed
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M. Korner, M. Stockli, B. Waser, J.C. Reubi, GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting. J. Nucl. Med. 48, 736–743 (2007)CrossRefPubMed
Metadata
Title
Preoperative localization of adult nesidioblastosis using 68Ga-DOTA-exendin-4-PET/CT
Authors
Emanuel Christ
Damian Wild
Kwadwo Antwi
Beatrice Waser
Melpomeni Fani
Stefanie Schwanda
Tobias Heye
Christoph Schmid
Hans Ulrich Baer
Aurel Perren
Jean Claude Reubi
Publication date
01-12-2015
Publisher
Springer US
Published in
Endocrine / Issue 3/2015
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-015-0633-7

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At a glance: The STEP trials

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A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

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