Published in:
01-04-2013 | Research Letter
Chief cell and clear cell parathyroid adenoma do not influence clinical and biochemical expression of the sporadic primary hyperparathyroidism
Authors:
Shweta Varshney, Sanjay Kumar Bhadada, Uma Nahar, Viral N. Shah, Anil Bhansali, Arnanshu Behera
Published in:
Endocrine
|
Issue 2/2013
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Excerpt
Primary hyperparathyroidism (PHPT) is a common endocrine disorder and the most common cause of PHPT is parathyroid adenoma [
1]. The normal parathyroid gland is composed of three types of cells—chief (50–60 %), clear (30–40 %), and oxyphil cells (<5 %) [
2]. The chief cells have slightly eosinophilic cytoplasm and contain few mitochondria and these cells mainly secrete parathyroid hormone (PTH) [
2]. Clear cells, which contain excessive cytoplasmic glycogen, are formed from chief cells while oxyphil cells have an intensely eosinophilic cytoplasm enriched with numerous and tightly packed mitochondria [
3]. The function of clear and oxyphil cells is still not clear [
2,
3]. …
