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Endocrine
Published in: Endocrine 1/2011

01-02-2011 | Original Article

GnRH secretion is inhibited by adiponectin through activation of AMP-activated protein kinase and extracellular signal-regulated kinase

Authors: Xiao-Bing Cheng, Jun-Ping Wen, Jun Yang, Ying Yang, Guang Ning, Xiao-Ying Li

Published in: Endocrine | Issue 1/2011

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Abstract

Adipokines produced from adipose tissues participate in regulation of reproduction, energy homeostasis, food intake, and neuroendocrine function in the hypothalamus. We have previously reported that adiponectin significantly reduced GnRH secretion from GT1-7 hypothalamic GnRH neuron cells. In this study, we further investigated the inhibition of GnRH secretion by adiponectin in vivo and found that extracellular signal-regulated kinase (ERK) was inhibited and AMPK activated. Furthermore, we found that activated AMPK by adiponectin reduced ERK phosphorylation, which possibly impaired GnRH secretion in GT1-7 cells.
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Metadata
Title
GnRH secretion is inhibited by adiponectin through activation of AMP-activated protein kinase and extracellular signal-regulated kinase
Authors
Xiao-Bing Cheng
Jun-Ping Wen
Jun Yang
Ying Yang
Guang Ning
Xiao-Ying Li
Publication date
01-02-2011
Publisher
Springer US
Published in
Endocrine / Issue 1/2011
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-010-9375-8

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