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01-12-2019 | Stroke | Original Paper

Preserving Mitochondrial Structure and Motility Promotes Recovery of White Matter After Ischemia

Authors: Chinthasagar Bastian, Jerica Day, Stephen Politano, John Quinn, Sylvain Brunet, Selva Baltan

Published in: NeuroMolecular Medicine | Issue 4/2019

Abstract

Stroke significantly affects white matter in the brain by impairing axon function, which results in clinical deficits. Axonal mitochondria are highly dynamic and are transported via microtubules in the anterograde or retrograde direction, depending upon axonal energy demands. Recently, we reported that mitochondrial division inhibitor 1 (Mdivi-1) promotes axon function recovery by preventing mitochondrial fission only when applied during ischemia. Application of Mdivi-1 after injury failed to protect axon function. Interestingly, L-NIO, which is a NOS3 inhibitor, confers post-ischemic protection to axon function by attenuating mitochondrial fission and preserving mitochondrial motility via conserving levels of the microtubular adaptor protein Miro-2. We propose that preventing mitochondrial fission protects axon function during injury, but that restoration of mitochondrial motility is more important to promote axon function recovery after injury. Thus, Miro-2 may be a therapeutic molecular target for recovery following a stroke.

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Title: Preserving Mitochondrial Structure and Motility Promotes Recovery of White Matter After Ischemia
Authors: Chinthasagar Bastian
Jerica Day
Stephen Politano
John Quinn
Sylvain Brunet
Selva Baltan
Publication date: 01-12-2019
Publisher: Springer US
Keyword: Stroke
Published in: NeuroMolecular Medicine / Issue 4/2019
Print ISSN: 1535-1084
Electronic ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-019-08550-w

At a glance: The ONWARDS insulin icodec trials

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Preserving Mitochondrial Structure and Motility Promotes Recovery of White Matter After Ischemia

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At a glance: The ONWARDS insulin icodec trials

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