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Published in: NeuroMolecular Medicine 4/2018

01-12-2018 | Review Paper

Aberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma

Authors: Wanli Yu, Sai Liang, Chunzhi Zhang

Published in: NeuroMolecular Medicine | Issue 4/2018

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Abstract

GBM is the highest incidence in primary intracranial malignancy, and it remains poor prognosis even though the patient is gave standard treatment. Despite decades of intense research, the complex biology of GBM remains elusive. In view of eight hallmarks of cancer which were proposed in 2011, studies related to the eight biological capabilities in GBM have made great progress. From these studies, it can be inferred that miRs, as a mode of post-transcriptional regulation, are involved in regulating these malignant biological hallmarks of GBM. Herein, we discuss state-of-the-art research on how aberrant miRs modulate the eight hallmarks of GBM. The upregulation of ‘oncomiRs’ or the genetic loss of tumor suppressor miRs is associated with these eight biological capabilities acquired during GBM formation. Furthermore, we also discuss the applicable clinical potential of these research results. MiRs may aid in the diagnosis and prognosis of GBM. Moreover, miRs are also therapeutic targets of GBM. These studies will develop and improve precision medicine for GBM in the future.
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Metadata
Title
Aberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma
Authors
Wanli Yu
Sai Liang
Chunzhi Zhang
Publication date
01-12-2018
Publisher
Springer US
Published in
NeuroMolecular Medicine / Issue 4/2018
Print ISSN: 1535-1084
Electronic ISSN: 1559-1174
DOI
https://doi.org/10.1007/s12017-018-8507-9

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