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01-03-2010 | Review Paper

An Overview of APP Processing Enzymes and Products

Authors: Vivian W. Chow, Mark P. Mattson, Philip C. Wong, Marc Gleichmann

Published in: NeuroMolecular Medicine | Issue 1/2010

Abstract

The generation of amyloid β-peptide (Aβ) by enzymatic cleavages of the β-amyloid precursor protein (APP) has been at the center of Alzheimer’s disease (AD) research. While the basic process of β- and γ-secretase-mediated generation of Aβ is text book knowledge, new aspects of Aβ and other cleavage products have emerged in recent years. Also our understanding of the enzymes involved in APP proteolysis has increased dramatically. All of these discoveries contribute to a more complete understanding of APP processing and the physiologic and pathologic roles of its secreted and intracellular protein products. Understanding APP processing is important for any therapeutic strategy aimed at reducing Aβ levels in AD. In this review, we provide a concise description of the current state of understanding the enzymes involved in APP processing, the cleavage products generated by different processing patterns, and the potential functions of those cleavage products.

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Title: An Overview of APP Processing Enzymes and Products
Authors: Vivian W. Chow
Mark P. Mattson
Philip C. Wong
Marc Gleichmann
Publication date: 01-03-2010
Publisher: Humana Press Inc
Published in: NeuroMolecular Medicine / Issue 1/2010
Print ISSN: 1535-1084
Electronic ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-009-8104-z

At a glance: The STEP trials

Springer Medicine

An Overview of APP Processing Enzymes and Products

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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