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Clinical Reviews in Allergy & Immunology

Published in:

01-08-2016

The Impact of Conventional and Biological Disease Modifying Antirheumatic Drugs on Bone Biology. Rheumatoid Arthritis as a Case Study

Authors: Sofia Carvalho Barreira, João Eurico Fonseca

Published in: Clinical Reviews in Allergy & Immunology | Issue 1/2016

Abstract

The bone and the immune system have a very tight interaction. Systemic immune-mediated inflammatory diseases, such as rheumatoid arthritis (RA), induce bone loss, leading to a twofold increase in osteoporosis and an increase of fragility fracture risk of 1.35–2.13 times. This review focuses on the effects of conventional and biological disease modifying antirheumatic drugs (DMARDs) on bone biology, in the context of systemic inflammation, with a focus on RA. Published evidence supports a decrease in osteoclastic activity induced by DMARDs, which leads to positive effects on bone mineral density (BMD). It is unknown if this effect could be translated into fracture risk reduction. The combination with antiosteoclastic drugs can have an additional benefit.

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Title: The Impact of Conventional and Biological Disease Modifying Antirheumatic Drugs on Bone Biology. Rheumatoid Arthritis as a Case Study
Authors: Sofia Carvalho Barreira
João Eurico Fonseca
Publication date: 01-08-2016
Publisher: Springer US
Published in: Clinical Reviews in Allergy & Immunology / Issue 1/2016
Print ISSN: 1080-0549
Electronic ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-016-8547-6

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