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Clinical Reviews in Allergy & Immunology

Published in:

01-10-2007

Recent Advances on Pathogenesis and Therapies in Systemic Sclerosis

Authors: Norihito Yazawa, Manabu Fujimoto, Kunihiko Tamaki

Published in: Clinical Reviews in Allergy & Immunology | Issue 1-2/2007

Abstract

Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by extensive fibrotic changes in various organs, including skin and lung. Although the etiology of SSc remains unknown, three major abnormalities, abnormal humoral immunity, microvasculature, and fibroblast dysfunctions are considered to play important roles. Significant progress has been made in understanding the pathogenesis on SSc, and has been also providing clues to the treatment for this disease. This review summarizes recent advances on the pathogenesis and new therapeutic strategy for SSc.

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Title: Recent Advances on Pathogenesis and Therapies in Systemic Sclerosis
Authors: Norihito Yazawa
Manabu Fujimoto
Kunihiko Tamaki
Publication date: 01-10-2007
Publisher: Humana Press Inc
Published in: Clinical Reviews in Allergy & Immunology / Issue 1-2/2007
Print ISSN: 1080-0549
Electronic ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-007-8009-2

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