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Clinical Reviews in Allergy & Immunology
Published in: Clinical Reviews in Allergy & Immunology 1-2/2007

01-10-2007

Pathophysiology of Cutaneous Lupus Erythematosus

Authors: Julie H. Lin, Jan P. Dutz, Richard D. Sontheimer, Victoria P. Werth

Published in: Clinical Reviews in Allergy & Immunology | Issue 1-2/2007

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Abstract

Cutaneous lupus erythematosus (LE; syn LE-specific skin disease) is an autoimmune disease with well-defined skin manifestations often accentuated in a photodistribution and frequently associated with specific autoantibodies. These clinical observations have led to numerous laboratory studies related to the role of ultraviolet light, as well as studies of the cascade of immunologic events involved in the pathogenesis of cutaneous LE. We discuss the epidemiologic, clinical, and laboratory findings of cutaneous LE, including the classification of disease subsets. We review the evidence for abnormal photoreactivity in LE with an overview of the cellular, molecular, and genetic factors that may underlie this abnormality. As there is yet no convincing animal model of cutaneous LE, many studies remain descriptive in nature. To arrive at an understanding of the potential mechanisms underlying the development of cutaneous lupus, we discuss the role of ultraviolet light-mediated induction of apoptosis, antigen presentation, genetic factors, and mediators of inflammation. In addition, we consider the role and importance of humoral and cellular factors, synthesizing the current understanding of the pathophysiology of cutaneous lupus.
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Metadata
Title
Pathophysiology of Cutaneous Lupus Erythematosus
Authors
Julie H. Lin
Jan P. Dutz
Richard D. Sontheimer
Victoria P. Werth
Publication date
01-10-2007
Publisher
Humana Press Inc
Published in
Clinical Reviews in Allergy & Immunology / Issue 1-2/2007
Print ISSN: 1080-0549
Electronic ISSN: 1559-0267
DOI
https://doi.org/10.1007/s12016-007-0031-x

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