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Cardiovascular Toxicology
Published in: Cardiovascular Toxicology 7/2022

04-05-2022 | Alopecia

Evaluating the Role of lncRNAs in the Incidence of Cardiovascular Diseases in Androgenetic Alopecia Patients

Authors: Masoumeh Roohaninasab, Shadnaz fakhteh yavari, Motahareh Babazadeh, Rozita Adldoosti Hagh, Mahboubeh Pazoki, Mehran Amrovani

Published in: Cardiovascular Toxicology | Issue 7/2022

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Abstract

Hair loss occurs in patients with Androgenetic Alopecia (AGA). The pattern of hair loss is different between men and women. The main cause of hair loss is increased cell apoptosis and decreased regeneration, proliferation and differentiation processes in hair follicles. Long Non-Coding RNAs (lncRNAs) are one of the most important molecules that regulate the processes of apoptosis, regeneration, proliferation and differentiation in hair follicles. Since studies have shown that lncRNAs can be effective in the development of cardiotoxicity and induction of cardiovascular disease (CVD); so effective lncRNAs in the regulation of regeneration, proliferation, differentiation and apoptosis of hair follicles can be involved in the development of CVD in AGA patients with. Therefore, this study investigated the lncRNAs involved in increasing apoptosis and reducing the processes of regeneration, proliferation and differentiation of hair follicles. The aim of the current study was to evaluate the role of lncRNAs as a risk factor in the incidence of CVD in AGA patients; it will help to design treatment strategies by targeting signaling pathways without any cardiotoxicity complications.
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Metadata
Title
Evaluating the Role of lncRNAs in the Incidence of Cardiovascular Diseases in Androgenetic Alopecia Patients
Authors
Masoumeh Roohaninasab
Shadnaz fakhteh yavari
Motahareh Babazadeh
Rozita Adldoosti Hagh
Mahboubeh Pazoki
Mehran Amrovani
Publication date
04-05-2022
Publisher
Springer US
Keyword
Alopecia
Published in
Cardiovascular Toxicology / Issue 7/2022
Print ISSN: 1530-7905
Electronic ISSN: 1559-0259
DOI
https://doi.org/10.1007/s12012-022-09742-w

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