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Clinical Orthopaedics and Related Research®

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01-10-2015 | From Bench to Bedside

From Bench to Bedside: Alpha-defensin—The Biggest Thing in Joint Replacement Infections Since Prophylactic Antibiotics?

Author: Benjamin K. Potter, MD

Published in: Clinical Orthopaedics and Related Research® | Issue 10/2015

Excerpt

We have been awaiting the arrival of 21^st century biomarker-, gene- or sequence-driven personalized medicine since well before the millennium. Yet the “Golden Age” of personalized medicine has proven elusive. While total joint arthroplasty (TJA) alleviates suffering perhaps better than any other orthopaedic intervention [8], patients whose arthroplasties have been complicated by infection have a very different experience. The condition is painful, the treatments are inconsistent, and most vexingly, our approaches to diagnosing the condition fall well short of what our patients expect from us in the second decade of the 21^st century. …

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Title: From Bench to Bedside: Alpha-defensin—The Biggest Thing in Joint Replacement Infections Since Prophylactic Antibiotics?
Author: Benjamin K. Potter, MD
Publication date: 01-10-2015
Publisher: Springer US
Published in: Clinical Orthopaedics and Related Research® / Issue 10/2015
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI: https://doi.org/10.1007/s11999-015-4297-7

At a glance: The STEP trials

Springer Medicine

From Bench to Bedside: Alpha-defensin—The Biggest Thing in Joint Replacement Infections Since Prophylactic Antibiotics?

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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