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Clinical Orthopaedics and Related Research®

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01-08-2009 | Symposium: Biomechanics of Bone Healing

Parecoxib and Indomethacin Delay Early Fracture Healing: A Study in Rats

Authors: Sigbjorn Dimmen, MD, Lars Nordsletten, MD, PhD, Jan Erik Madsen, MD, PhD

Published in: Clinical Orthopaedics and Related Research® | Issue 8/2009

Abstract

Nonsteroidal antiinflammatory drugs (NSAIDs) are used to reduce inflammatory response and pain. These drugs have been reported to impair bone metabolism. Parecoxib, a specific COX-2 inhibitor, exerts an inhibitory effect on the mineralization of fracture callus after a tibial fracture in rats. Decreased bone mineral density (BMD) at a fracture site may indicate impairment of early healing, casting doubt on the safety of using COX-2 inhibitors during the early treatment of diaphyseal fractures. Forty-two female Wistar rats were randomly allocated to three groups. They were given parecoxib, indomethacin, or saline intraperitoneally for 7 days after being subjected to a closed tibial fracture stabilized with an intramedullary nail. Two and 3 weeks after surgery, the bone density at the fracture site was measured using dual energy xray absorptiometry (DEXA). Three weeks after the operation the rats were euthanized and the healing fractures were mechanically tested in three-point cantilever bending. Parecoxib decreased BMD at the fracture site for 3 weeks after fracture, indomethacin for 2 weeks. Both parecoxib and indomethacin reduced the ultimate bending moment and the bending stiffness of the healing fractures after 3 weeks. These results suggest COX inhibitors should be avoided in the early phase after fractures.

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Title: Parecoxib and Indomethacin Delay Early Fracture Healing: A Study in Rats
Authors: Sigbjorn Dimmen, MD
Lars Nordsletten, MD, PhD
Jan Erik Madsen, MD, PhD
Publication date: 01-08-2009
Publisher: Springer-Verlag
Published in: Clinical Orthopaedics and Related Research® / Issue 8/2009
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI: https://doi.org/10.1007/s11999-009-0783-0

At a glance: The STEP trials

Springer Medicine

Parecoxib and Indomethacin Delay Early Fracture Healing: A Study in Rats

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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